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Pharmacogenetics and Toxicology Publisher



Hasanzad M1, 2 ; Sarhangi N1 ; Aghaei Meybodi HR3 ; Nikfar S1, 4
Authors
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Authors Affiliations
  1. 1. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy and Pharmaceutical Policy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 Published:2023


Abstract

Aim: The aim of the present review is to discuss the association of evidence-based pharmacogenomics (PGx) variants with some therapeutic information (mainly toxicity). Main concepts: Pharmacogenomics studies enable the recognition of variable therapeutic responses, the prediction of adverse drug reactions (ADRs) or toxicity, and the development and discovery of new drugs. Conclusion: There is sufficient scientific evidence to suggest that subgroups of patients with specific genetic variants or genetic variant-inferred phenotypes are likely to have altered drug metabolism and, in some cases, differential therapeutic effects, including differences in the risks of adverse events—such as drug toxicity according to the food and drug administration (FDA) pharmacogenetic associations. © 2024 Elsevier Inc. All rights reserved.
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