Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities

Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities Publisher Pubmed

Khodaparast M¹ ; Shahraki K¹ ; Jabbarvand M¹ ; Shahraki K¹ ; Rafat M^{3, 4} ; Moravvej Z⁵

Show Affiliations

1. Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran
2. Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Biomedical Engineering, Linkoping University, Linkoping, Sweden
4. LinkoCare Life Sciences AB, Linkoping, Sweden
5. Eye Research Center, Eye Department, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Source: Cornea Published:2020

Abstract

Purpose:To evaluate the safety and efficacy of a bioengineered corneal implant using femtosecond laser-assisted anterior lamellar keratoplasty for superficial corneal opacities.Methods:Six eyes of 6 consecutive patients with superficial corneal stromal opacities involving <220 m owing to various pathologies were included in the study. Preoperatively, all patients underwent anterior segment optical coherence tomography (Visante; Carl Zeiss Meditec AG) to evaluate the depth of the corneal opacity. All patients underwent sutureless femtosecond laser-assisted anterior lamellar keratoplasty using a bioengineered collagen corneal implant (linkcor). Visual indices, refraction, and keratometry were evaluated preoperatively and 12 months postoperatively.Results:Corrected distance visual acuity improved significantly in all patients (P = 0.02). A significant decrease was seen in refractive astigmatism postoperatively (P = 0.04). Flat keratometry reduced significantly 12 months after the intervention (P = 0.04). No intraoperative or early postoperative complications were noticed. All implants were fully covered by healthy epithelium within a month after the surgery and remained clear at follow-up visits. The results of this procedure remained stable throughout the follow-up period. In 1 patient, mild inferior collagen melting and epithelial defect formation occurred at 1-year follow-up. Despite frequent topical corticosteroid therapy the melting progressed, the collagen tissue was removed and the patient was treated accordingly with good visual outcomes.Conclusions:Femtosecond laser-assisted anterior lamellar keratoplasty with bioengineered corneal (linkcor) implantation is an effective treatment for improving vision quality in anterior stromal opacities. This procedure reduces the need for human donor tissue and avoids human donor-related and suturing complications. © 2020 Lippincott Williams and Wilkins. All rights reserved.

2. Corneal Repair and Regeneration: Current Concepts and Future Directions, Frontiers in Bioengineering and Biotechnology (2019)

3. Updates on Managements for Keratoconus, Journal of Current Ophthalmology (2018)

4. Biological Materials Introduced to the Market for Blurred Cornea Regeneration, Regenerative Engineering and Translational Medicine (2023)

Experts (# of related papers)

Mehrdad Mohammadpour (1)

Mahmood Jabbarvand Behrouz (1)

Style	Citing Format
MLA	Khodaparast M, et al.. "Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities." Cornea, vol. 39, no. 9, 2020, pp. 1184-1189.
APA	Khodaparast M, Shahraki K, Jabbarvand M, Shahraki K, Rafat M, Moravvej Z (2020). Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities. Cornea, 39(9), 1184-1189.
Chicago	Khodaparast M, Shahraki K, Jabbarvand M, Shahraki K, Rafat M, Moravvej Z. "Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities." Cornea 39, no. 9 (2020): 1184-1189.
Harvard	Khodaparast M et al. (2020) 'Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities', Cornea, 39(9), pp. 1184-1189.
Vancouver	Khodaparast M, Shahraki K, Jabbarvand M, Shahraki K, Rafat M, Moravvej Z. Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities. Cornea. 2020;39(9):1184-1189.
BibTex	@article{ author = {Khodaparast M and Shahraki K and Jabbarvand M and Shahraki K and Rafat M and Moravvej Z}, title = {Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities}, journal = {Cornea}, volume = {39}, number = {9}, pages = {1184-1189}, year = {2020} }
RIS	TY - JOUR AU - Khodaparast M AU - Shahraki K AU - Jabbarvand M AU - Shahraki K AU - Rafat M AU - Moravvej Z TI - Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities JO - Cornea VL - 39 IS - 9 SP - 1184 EP - 1189 PY - 2020 ER -

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