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Novel Carboxymethyl Cellulose-Halloysite-Polyethylene Glycol Nanocomposite for Improved 5-Fu Delivery Publisher Pubmed



Ghasemizadeh H1 ; Pourmadadi M1 ; Yazdian F2 ; Rashedi H1 ; Navaeinigjeh M3, 4 ; Rahdar A5 ; Diezpascual AM6
Authors
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Authors Affiliations
  1. 1. Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  2. 2. Department of Life Science Engineering, Faculty of New Science and Technologies, University of Tehran, Tehran, Iran
  3. 3. Pharmaceutical Sciences Research Center, the Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Department of Physics, Faculty of Sciences, University of Zabol, Zabol, 538-98615, Iran
  6. 6. Universidad de Alcala, Facultad de Ciencias, Departamento de Quimica Analitica, Quimica Fisica e Ingenieria Quimica, Ctra. Madrid-Barcelona Km. 33.6, Madrid, Alcala de Henares, 28805, Spain

Source: International Journal of Biological Macromolecules Published:2023


Abstract

Drug nano-carriers are crucial for achieving targeted treatment against cancer disorders with minimal side effects. In this study, a pH-responsive nanocomposite based on halloysite nanotube (HNT) coated with carboxymethyl cellulose (CMC)/polyethylene glycol (PEG) hydrogel for controlled delivery of 5-Fluorouracil (5-FU), a hydrophobic chemotherapy drug prescribed for different types of cancers was synthesized for the first time using the water-in-oil-in-water (W/O/W) technique. The developed CMC/PEG/HNT/5-FU nanocomposite was characterized by dynamic light scattering (DLS), zeta potential, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Field emission scanning electron microscope (FE-SEM) to get information about the particle size, surface charge, interactions between functional groups, crystalline structure and morphology, respectively. High efficiencies in terms of drug entrapment and loading (46 % and 87 %, respectively) were attained. In-vitro drug release results revealed an improved and sustained 5-FU delivery in an acid environment compared to the physiological medium, corroborating the pH-sensitivity of the developed nano-carrier. Flow cytometry and MTT assays demonstrated that the 5-FU loaded nanocomposite had considerable cytotoxicity on MCF-7 breast cancer cells while it is not toxic against L929 fibroblast cells. The nanocomposite synthesized herein could serve as a platform for the pH-sensitive release of anti-cancer drugs. © 2023
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