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Ph-Sensitive Stimulus-Responsive Nanocarriers for Targeted Delivery of Therapeutic Agents Publisher Pubmed



Karimi M1 ; Eslami M2 ; Sahandizangabad P1, 3 ; Mirab F2 ; Farajisafiloo N2 ; Shafaei Z4 ; Ghosh D5 ; Bozorgomid M6 ; Dashkhaneh F7 ; Hamblin MR8, 9, 10
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Polymeric Materials Research Group, Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
  3. 3. Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
  4. 4. Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
  5. 5. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran university of Medical science, Tehran, Iran
  6. 6. Department of Applied Chemistry, Central Branch of Islamic Azad University of Tehran, Tehran, Iran
  7. 7. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran university of Medical Science, Tehran, Iran
  8. 8. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, United States
  9. 9. Department of Dermatology, Harvard Medical School, Boston, MA, United States
  10. 10. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology Published:2016


Abstract

In recent years miscellaneous smart micro/nanosystems that respond to various exogenous/endogenous stimuli including temperature, magnetic/electric field, mechanical force, ultrasound/light irradiation, redox potentials, and biomolecule concentration have been developed for targeted delivery and release of encapsulated therapeutic agents such as drugs, genes, proteins, and metal ions specifically at their required site of action. Owing to physiological differences between malignant and normal cells, or between tumors and normal tissues, pH-sensitive nanosystems represent promising smart delivery vehicles for transport and delivery of anticancer agents. Furthermore, pH-sensitive systems possess applications in delivery of metal ions and biomolecules such as proteins, insulin, etc., as well as co-delivery of cargos, dual pH-sensitive nanocarriers, dual/multi stimuli-responsive nanosystems, and even in the search for new solutions for therapy of diseases such as Alzheimer's. In order to design an optimized system, it is necessary to understand the various pH-responsive micro/nanoparticles and the different mechanisms of pH-sensitive drug release. This should be accompanied by an assessment of the theoretical and practical challenges in the design and use of these carriers. WIREs Nanomed Nanobiotechnol 2016, 8:696–716. doi: 10.1002/wnan.1389. For further resources related to this article, please visit the WIREs website. © 2016 Wiley Periodicals, Inc.
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