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Obesity and Pro12ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis Publisher Pubmed



Mansoori A1 ; Amini M2 ; Kolahdooz F3 ; Seyedrezazadeh E3
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Nutrition Department, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Annals of Nutrition and Metabolism Published:2015


Abstract

Background: The aim of this systematic review was to evaluate the relationship between obesity and peroxisome proliferator-activated receptor-gamma (PPARγ) Pro12Ala polymorphism in healthy adults. Summary: Weighted mean differences (WMDs) of body mass index (BMI) were calculated for different inheritance models and subgroups. Fifty-six studies were eligible for inclusion in the meta-analysis. The result shows that the Ala allele of this polymorphism was associated with increased WMD in mean BMI (WMD = 0.29, 95% CI 0.10-0.48, p = 0.003). The Ala carriers were associated with increased WMD in mean BMI values in both genders and in the Caucasian subgroup. The associations were seen among people with higher levels of BMI (BMI ≥35). Message: The Ala allele of the PPARγ Pro12Ala polymorphism in healthy adults was associated with increased BMI under a dominant model of inheritance. © 2015 S. Karger AG, Basel.
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