Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A

Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A Publisher Pubmed

Soori S¹ ; Dadashizadeh G² ; Dorgalaleh A¹ ; Tabibian S¹ ; Keramati MR² ; Alizadeh S³ ; Hosseini MS⁴ ; Zaker F^{1, 5} ; Shams M^{1, 6}

Show Affiliations

1. Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
2. Department of Hematology and Blood Transfusion, School of Allied Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Hematology and Blood Transfusion, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Hematology and Blood Transfusion, School of Allied Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Cellular and Molecular Research Center, Department of Hematology, Faculty of Allied Medicine, Iran University of Medical Science, Tehran, Iran
6. Department of Medical Laboratory, Faculty of Paramedical Science, Babol University of Medical Science, Babol, Iran

Source: Cardiovascular and Hematological Disorders - Drug Targets Published:2019

Abstract

Background: About one-fourth of patients with hemophilia A (HA) develop alloantibodies against factor (F) VIII, as the main treatment challenge. Here, we assessed the relationship between interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), FII and FV polymorphisms and risk of inhibitor formation in patients with severe HA. Methods: We divided 39 patients with severe HA in two groups of case (n: 19) and control (n: 20). Genotyping was performed by multiplex amplification tetra arms refractory mutation systempolymerase chain reaction (ARMS-PCR) and PCR-restriction fragment-length polymorphism (PCR-RFLP). Results: TNFα rs1800629 G>A polymorphism decreased the risk of inhibitor development in codominant and dominant inheritance pattern. Moreover, TNFα rs1800629 A allele, decrease the risk of inhibitor formation, while IL10 rs1800896 A>G, FV rs6025 G>A, and FII rs1799963 G>A polymorphisms were not associated with risk of inhibitor development. Conclusion: It seems that TNFα rs1800629 G>A polymorphism decreased the risk of inhibitor formation in Iranian patients with HA. © 2019 Bentham Science Publishers.

Style	Citing Format
MLA	Soori S, et al.. "Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A." Cardiovascular and Hematological Disorders - Drug Targets, vol. 19, no. 3, 2019, pp. 228-232.
APA	Soori S, Dadashizadeh G, Dorgalaleh A, Tabibian S, Keramati MR, Alizadeh S, Hosseini MS, Zaker F, Shams M (2019). Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A. Cardiovascular and Hematological Disorders - Drug Targets, 19(3), 228-232.
Chicago	Soori S, Dadashizadeh G, Dorgalaleh A, Tabibian S, Keramati MR, Alizadeh S, Hosseini MS, Zaker F, Shams M. "Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A." Cardiovascular and Hematological Disorders - Drug Targets 19, no. 3 (2019): 228-232.
Harvard	Soori S et al. (2019) 'Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A', Cardiovascular and Hematological Disorders - Drug Targets, 19(3), pp. 228-232.
Vancouver	Soori S, Dadashizadeh G, Dorgalaleh A, Tabibian S, Keramati MR, Alizadeh S, et al.. Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A. Cardiovascular and Hematological Disorders - Drug Targets. 2019;19(3):228-232.
BibTex	@article{ author = {Soori S and Dadashizadeh G and Dorgalaleh A and Tabibian S and Keramati MR and Alizadeh S and Hosseini MS and Zaker F and Shams M}, title = {Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A}, journal = {Cardiovascular and Hematological Disorders - Drug Targets}, volume = {19}, number = {3}, pages = {228-232}, year = {2019} }
RIS	TY - JOUR AU - Soori S AU - Dadashizadeh G AU - Dorgalaleh A AU - Tabibian S AU - Keramati MR AU - Alizadeh S AU - Hosseini MS AU - Zaker F AU - Shams M TI - Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A JO - Cardiovascular and Hematological Disorders - Drug Targets VL - 19 IS - 3 SP - 228 EP - 232 PY - 2019 ER -

Style

Citing Format

MLA

Soori S, et al.. "Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A." Cardiovascular and Hematological Disorders - Drug Targets, vol. 19, no. 3, 2019, pp. 228-232.

APA

Soori S, Dadashizadeh G, Dorgalaleh A, Tabibian S, Keramati MR, Alizadeh S, Hosseini MS, Zaker F, Shams M (2019). Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A. Cardiovascular and Hematological Disorders - Drug Targets, 19(3), 228-232.

Chicago

Soori S, Dadashizadeh G, Dorgalaleh A, Tabibian S, Keramati MR, Alizadeh S, Hosseini MS, Zaker F, Shams M. "Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A." Cardiovascular and Hematological Disorders - Drug Targets 19, no. 3 (2019): 228-232.

Harvard

Soori S et al. (2019) 'Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A', Cardiovascular and Hematological Disorders - Drug Targets, 19(3), pp. 228-232.

Vancouver

Soori S, Dadashizadeh G, Dorgalaleh A, Tabibian S, Keramati MR, Alizadeh S, et al.. Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A. Cardiovascular and Hematological Disorders - Drug Targets. 2019;19(3):228-232.

BibTex

@article{ author = {Soori S and Dadashizadeh G and Dorgalaleh A and Tabibian S and Keramati MR and Alizadeh S and Hosseini MS and Zaker F and Shams M}, title = {Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A}, journal = {Cardiovascular and Hematological Disorders - Drug Targets}, volume = {19}, number = {3}, pages = {228-232}, year = {2019} }

RIS

TY - JOUR
AU - Soori S
AU - Dadashizadeh G
AU - Dorgalaleh A
AU - Tabibian S
AU - Keramati MR
AU - Alizadeh S
AU - Hosseini MS
AU - Zaker F
AU - Shams M
TI - Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor Ii and Factor V With Risk of Inhibitor Development in Patients With Severe Hemophilia A
JO - Cardiovascular and Hematological Disorders - Drug Targets
VL - 19
IS - 3
SP - 228
EP - 232
PY - 2019
ER -

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Abstract