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The Association of Fat-Mass-And Obesity-Associated Gene Polymorphism (Rs9939609) With Colorectal Cancer: A Case-Control Study Publisher



Gholamalizadeh M1 ; Akbari ME2 ; Doaei S3 ; Davoodi SH4 ; Bahar B5 ; Tabesh GA6 ; Sadeghi H7 ; Razavi Hashemi M8 ; Kheyrani E9 ; Rastgoo S4 ; Hajipour A10 ; Aslany Z6 ; Mirfakhraie R6 ; Mosavi Jarrahi A11
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Research Center of Health and Environment, School of Health, Guilan University of Medical Sciences, Rasht, Iran
  4. 4. Departments of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport Health Sciences, University of Central Lancashire, Preston, United Kingdom
  6. 6. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Pathology, Firoozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Taban Medical Genetic Laboratory, Tehran, Iran
  10. 10. School of Health, Qazvin University of Medical Sciences, Qazvin, Iran
  11. 11. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Oncology Published:2021


Abstract

Background and Aim: The association between the rs9939609 polymorphism of fat mass and obesity-associated gene (FTO) and risk of colorectal cancer is controversial. This study aims to evaluate the relationship between FTO rs9939609 polymorphism and colorectal cancer (CRC) in Iranian people. Methods: A case-control study was conducted on 125 patients with CRC and 250 healthy subjects in Tehran, Iran. Demographic data and blood samples were collected from all participants. Genotyping of rs9939609 polymorphism was performed by the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) method. Results: The occurrence of AA genotype of FTO rs9939609 polymorphism in the colorectal cancer patients was significantly higher compared to that of healthy subjects (16.4 vs. 2.9%, respectively, P=0.02). The association between the frequency of risk allele of the FTO polymorphism and CRC (B=1.67, P=0.042) remained significant after adjustment for age. Further adjustment for gender (model 2) and marital status (model 3) did not change this result (B=1.67, P= 0.042 and B=1.67, P=0.043, respectively). The results remained significant after additional adjustment for ethnicity (B=1.57, P= 0.047). Conclusion: We found a positive association between the A allele of the rs9939609 polymorphism and CRC. Future studies are required to identify the underlying mechanisms. © Copyright © 2021 Gholamalizadeh, Akbari, Doaei, Davoodi, Bahar, Tabesh, Sadeghi, Razavi Hashemi, Kheyrani, Rastgoo, Hajipour, Aslany, Mirfakhraie and Mosavi Jarrahi.
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