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Interferons: Role in Cancer Therapy Publisher Pubmed



Abdolvahab MH1 ; Darvishi B1 ; Zarei M2, 3 ; Majidzadeha K1 ; Farahmand L1
Authors
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Authors Affiliations
  1. 1. Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, Acecr, Tehran, 1517964311, Iran
  2. 2. Department of Pathology and Laboratory Medicine, Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, 19104, PA, United States
  3. 3. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, PA, United States

Source: Immunotherapy Published:2020


Abstract

Interferons (IFNs) are a group of signaling cytokines, secreted by host cells to induce protection against various disorders. IFNs can directly impact on tumor cells or indirectly induce the immune system to protect host cells. The expression levels of IFNs and its functions of are excellently modulated in a way to protect host cells from probable toxicities caused by extreme responses. The efficacy of anticancer therapies is correlated to IFNs signaling. Although IFN signaling is involved in induction of antitumor responses, chronic stimulation of the IFN signaling pathway can induce resistance to various antineoplasm therapies. Hence, IFNs are expressed by both cancer and immune cells, and modulate their biological function. Understanding this mechanism of action might be a key target of combination therapies. © 2020 Future Medicine Ltd.
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