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Biological Function and Molecular Mechanism of Pirna in Cancer Publisher



Chalbatani GM1 ; Dana H3 ; Memari F1 ; Gharagozlou E1 ; Ashjaei S2 ; Kheirandish P1 ; Marmari V3 ; Mahmoudzadeh H1 ; Mozayani F1 ; Maleki AR1 ; Sadeghian E1 ; Nia EZ3 ; Miri SR1 ; Nia NZ4 Show All Authors
Authors
  1. Chalbatani GM1
  2. Dana H3
  3. Memari F1
  4. Gharagozlou E1
  5. Ashjaei S2
  6. Kheirandish P1
  7. Marmari V3
  8. Mahmoudzadeh H1
  9. Mozayani F1
  10. Maleki AR1
  11. Sadeghian E1
  12. Nia EZ3
  13. Miri SR1
  14. Nia NZ4
  15. Rezaeian O5
  16. Eskandary A5
  17. Razavi N6
  18. Shirkhoda M1
  19. Rouzbahani FN1
Show Affiliations
Authors Affiliations
  1. 1. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Paramedical Sciences, Islamic Azad University, Tehran Branch, Tehran, Iran
  3. 3. Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
  4. 4. Department of Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
  5. 5. Department of Biology, NourDanesh Institute of Higher Education, Isfahan, Iran
  6. 6. Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Practical Laboratory Medicine Published:2019


Abstract

Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer. © 2018 The Authors