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Novel Perspectives for the Diagnosis and Treatment of Gynecological Cancers Using Dysregulation of Piwi Protein and Pirnas As Biomarkers Publisher Pubmed



Yousefi B1, 2 ; Sadoughi F3 ; Asemi Z3 ; Mansournia MA4 ; Hallajzadeh J5
Authors
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Authors Affiliations
  1. 1. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biochemistry and Nutrition, Research Center for Evidence-Based Health Management, Maragheh University of Medical Sciences, Maragheh, Iran

Source: Current Medicinal Chemistry Published:2024


Abstract

The term “gynecological cancer” is used for a group of cancers occurring in the female reproductive system. Some of these cancers are ranked as the leading causes of death in developed and developing countries. The lack of proper diagnostic strategies is one of the most important reasons that make them lethal. PIWI-interacting RNAs or piRNAs are a class of small non-coding RNAs, which contain 24-32 nucleotides. These RNAs take part in some cellular mechanisms, and their role in diverse kinds of cancer is confirmed by accumulative evidence. In this review, we gather some information on the roles of these RNAs and members of the PIWI protein family to provide new insight into accurate diagnostic biomarkers and more effective anti-cancer drugs with fewer side effects. © 2024 Bentham Science Publishers.
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Mohammad Ali Mansournia (4)
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