Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Gynecologic Cancers and Non-Coding Rnas: Epigenetic Regulators With Emerging Roles Publisher Pubmed



Razavi ZS1 ; Tajiknia V2 ; Majidi S3 ; Ghandali M4 ; Mirzaei HR5 ; Rahimian N6 ; Hamblin MR7, 8, 9 ; Mirzaei H10
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Department of Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
  4. 4. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran
  7. 7. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, 02114, MA, United States
  8. 8. Department of Dermatology, Harvard Medical School, Boston, 02115, MA, United States
  9. 9. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa
  10. 10. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Critical Reviews in Oncology/Hematology Published:2021


Abstract

Gynecologic cancers involve the female genital organs, such as the vulva, vagina, cervix, endometrium, ovaries, and fallopian tubes. The occurrence and frequency of gynecologic cancer depends on personal lifestyle, history of exposure to viruses or carcinogens, genetics, body shape, and geographical habitat. For a long time, research into the molecular biology of cancer was broadly restricted to protein-coding genes. Recently it has been realized that non-coding RNAs (ncRNA), including long noncoding RNAs (LncRNAs), microRNAs, circular RNAs and piRNAs (PIWI-interacting RNAs), can all play a role in the regulation of cellular function within gynecological cancer. It is now known that ncRNAs are able to play dual roles, i.e. can exert both oncogenic or tumor suppressive functions in gynecological cancer. Moreover, several clinical trials are underway looking at the biomarker and therapeutic roles of ncRNAs. These efforts may provide a new horizon for the diagnosis and treatment of gynecological cancer. Herein, we summarize some of the ncRNAs that have been shown to be important in gynecological cancers. © 2020 Elsevier B.V.
Related Docs
View other Related Docs
1. Micrornas, Long Non-Coding Rnas, and Circular Rnas and Gynecological Cancers: Focus on Metastasis, Frontiers in Oncology (2023)
2. A New World of Biomarkers and Therapeutics for Female Reproductive System and Breast Cancers: Circular Rnas, Frontiers in Cell and Developmental Biology (2020)
3. The Role of Long Non-Coding Rnas and Circular Rnas in Cervical Cancer: Modulating Mirna Function, Frontiers in Cell and Developmental Biology (2024)
4. Circular Rnas in Alzheimer’S Disease: A New Perspective of Diagnostic and Therapeutic Targets, CNS and Neurological Disorders - Drug Targets (2023)
5. Circular Rnas and Gastrointestinal Cancers: Epigenetic Regulators With a Prognostic and Therapeutic Role, Critical Reviews in Oncology/Hematology (2020)
6. Circular Rnas in Tuberculosis: From Mechanism of Action to Potential Diagnostic Biomarker, Microbial Pathogenesis (2023)
7. Circ_0067934 As a Novel Therapeutic Target in Cancer: From Mechanistic to Clinical Perspectives, Pathology Research and Practice (2023)
8. Multiple Novel Functions of Circular Rnas in Diabetes Mellitus, Archives of Physiology and Biochemistry (2023)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (7)
Mohammad Ali Mansournia (6)
Other Related Docs
9. Non-Coding Rnas and Glioblastoma: Insight Into Their Roles in Metastasis, Molecular Therapy Oncolytics (2022)
10. Circrnas: A Novel Strategy in Diagnosis and Treatment of Thyroid Cancer, Current Molecular Medicine (2023)
11. The Critical Role of Circular Rnas in Drug Resistance in Gastrointestinal Cancers, Medical Oncology (2023)
12. Circular Rna; a New Biomarker for Breast Cancer: A Systematic Review, Journal of Cellular Physiology (2020)
13. An Overview of Long Noncoding Rnas: Biology, Functions, Therapeutics, Analysis Methods, and Bioinformatics Tools, Cell Biochemistry and Function (2022)
14. Novel Perspectives for the Diagnosis and Treatment of Gynecological Cancers Using Dysregulation of Piwi Protein and Pirnas As Biomarkers, Current Medicinal Chemistry (2024)
15. Constructing Mrna, Mirna, Circrna and Lncrna Regulatory Network by Analysis of Microarray Data in Breast Cancer, Gene Reports (2022)
16. Melatonin Targeting Non-Coding Rnas in Cancer: Focus on Mechanisms and Potential Therapeutic Targets, European Journal of Pharmacology (2023)
17. The Effects of Exercise on Epigenetic Modifications: Focus on Dna Methylation, Histone Modifications and Non-Coding Rnas, Human Cell (2024)
18. Cancer Stem Cells and Oral Cancer: Insights Into Molecular Mechanisms and Therapeutic Approaches, Cancer Cell International (2020)
19. The Effective Function of Circular Rna in Colorectal Cancer, Cancer Cell International (2021)
20. Autophagy and Gastrointestinal Cancers: The Behind the Scenes Role of Long Non-Coding Rnas in Initiation, Progression, and Treatment Resistance, Cancer Gene Therapy (2021)
21. Non-Coding Rnas in Leukemia Drug Resistance: New Perspectives on Molecular Mechanisms and Signaling Pathways, Annals of Hematology (2024)
22. Liquid Biopsy in Female Genital Tract (Ovarian Cancer, Endometrial Tumor, and Cervical Tumor), Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)
23. Circular Rnas (Circrnas) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets, Non-coding RNA Transcripts In Cancer Therapy: Pre-clinical And Clinical Implications (2023)
24. Piwi-Interacting Rnas: New Biomarkers for Diagnosis and Treatment of Breast Cancer, Cell and Bioscience (2020)
25. Exosomal Micrornas and Long Noncoding Rnas: Novel Mediators of Drug Resistance in Lung Cancer, Journal of Cellular Physiology (2022)
26. Critical Involvement of Circular Rnas in Virus-Associated Cancers, Genes and Diseases (2023)
27. Identification of Dysregulated Mirnas-Genes Network in Ovarian Cancer: An Integrative Approach to Uncover the Molecular Interactions and Oncomechanisms, Cancer Reports (2020)
28. The Landscape of Exosomal Non-Coding Rnas in Breast Cancer Drug Resistance, Focusing on Underlying Molecular Mechanisms, Frontiers in Pharmacology (2023)
29. A Systematic Review of Long Non-Coding Rnas With a Potential Role in Breast Cancer, Mutation Research - Reviews in Mutation Research (2021)
30. Angioregulatory Role of Mirnas and Exosomal Mirnas in Glioblastoma Pathogenesis, Biomedicine and Pharmacotherapy (2022)
31. Nlrp3 Inflammasome Pathway in Atherosclerosis: Focusing on the Therapeutic Potential of Non-Coding Rnas, Pathology Research and Practice (2023)
32. Circular Rnas in Renal Cell Carcinoma: Functions in Tumorigenesis and Diagnostic and Prognostic Potentials, Pathology Research and Practice (2022)
33. Critical Considerations for Investigating Micrornas During Tumorigenesis: A Case Study in Conceptual and Contextual Nuances of Mir-211-5P in Melanoma, Epigenomes (2023)
34. Role of Resveratrol in Modulating Micrornas in Human Diseases: From Cancer to Inflammatory Disorder, Current Medicinal Chemistry (2021)
35. Role of Non-Coding Rnas and Exosomal Non-Coding Rnas in Retinoblastoma Progression, Frontiers in Cell and Developmental Biology (2022)
36. Microrna and Gynecological Cancers: Focus on Mir-195, Pathology Research and Practice (2023)
37. How Micrornas Affect the Pd-L1 and Its Synthetic Pathway in Cancer, International Immunopharmacology (2020)
38. Ovarian Cancer in the World: Epidemiology and Risk Factors, International Journal of Women's Health (2019)
39. Virus, Exosome, and Microrna: New Insights Into Autophagy, Advances in Experimental Medicine and Biology (2022)
40. New Insights Into the Long Non-Coding Rnas Dependent Modulation of Heart Failure and Cardiac Hypertrophy: From Molecular Function to Diagnosis and Treatment, Current Medicinal Chemistry (2024)
41. Recent Advances on High-Efficiency of Micrornas in Different Types of Lung Cancer: A Comprehensive Review, Cancer Cell International (2023)
42. Micrornas and Exosomes: Cardiac Stem Cells in Heart Diseases, Pathology Research and Practice (2022)
43. The Role of Altered Long Noncoding Rnas in Overall Survival of Ovarian Cancer: A Systematic Review and Meta-Analysis, Pathology Research and Practice (2021)
44. Long Noncoding Rnas and Exosomal Lncrnas: Classification, and Mechanisms in Breast Cancer Metastasis and Drug Resistance, Oncogene (2020)
45. The Salivary Exosomal Microrna As a Potential Biomarker in Patients With Periodontitis and Oral Cancers, Chemical Biology and Drug Design (2023)
46. Mir-142-3P/5P Role in Cancer: From Epigenetic Regulation to Immunomodulation, Cell Biochemistry and Function (2024)
47. Gastrointestinal Cancer Drug Resistance: The Role of Exosomal Mirnas, Molecular Biology Reports (2022)
48. Micrornas As Novel Diagnostic Biomarkers in Endometriosis Patients: A Systematic Review and Meta-Analysis, Expert Review of Molecular Diagnostics (2022)
49. Cytokine Storm in the Pathophysiology of Covid-19: Possible Functional Disturbances of Mirnas, International Immunopharmacology (2021)
50. Non-Coding Rnas and Exosomal Non-Coding Rnas in Traumatic Brain Injury: The Small Player With Big Actions, Molecular Neurobiology (2023)