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Effects of Imfluna, an Iranian Traditional Polyherbal Medicine, on Covid-19 Symptoms: A Randomized, Double-Blind and Placebo-Controlled Clinical Trial; [یک کارآزمایی بالینی تصادفی :Covid-19 تأثیرایمفلونا، یک داروی سنتی چند گیاهی ایرانی، بر علائم دوسو بیخبر کنترل شده با دارونما] Publisher



Huseini HF1 ; Gholibeikian M2 ; Shohrati M3 ; Kaffash A4 ; Taheri A5 ; Khajepour H6 ; Raei M7 ; Kianbakht S1 ; Hosseini AF8 ; Nohooji MG1 ; Mohtashami R9
Authors
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Authors Affiliations
  1. 1. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
  2. 2. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
  3. 3. Department of Pharmacotherapy, Faculty of Pharmacy, Baqiyatallah Uiversity of Medical Sciences, Tehran, Iran
  4. 4. Department of Internal Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
  5. 5. Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
  6. 6. Department of Radiology, Baqiyatallah University of Medical Sciences, Tehran, Iran
  7. 7. Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  8. 8. Department of Emergency Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Medicine Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Journal of Medicinal Plants Published:2022


Abstract

Background: The current pandemic of Coronavirus disease 2019 (COVID-19) and severity of the infection and high mortality have almost unprecedented challenges in the health systems of most countries around the world. Objective: The present study aimed to evaluate the effect of Iranian traditional polyherbal medicine (Imfluna) containing a mixture of echinacea, stachys, artemisia, hyssopus, polybody, alpinia, ginger, and ginseng extract on symptoms of COVID-19 infected patients. Methods: In this placebo-controlled and double-blind clinical trial, a total of 60 voluntarily approved patients with COVID-19 were randomly assigned to the placebo and Imfluna groups. Patients in each group, in addition to receiving standard medications, took two 500 mg capsules of Imfluna or placebo every 8 hours for 2 weeks. The patient's vital signs, including the severity of shortness of breath, cough, and body temperature, were recorded during the study. Also blood ESR, liver and kidney function tests were performed at baseline and endpoint. Results: The results showed that patients in the Imfluna-treated group had significantly greater improvement in daily cough, shortness of breath and ESR compared with the placebo group. In addition, lung lesions improved in the Imfluna-treated group, although not significantly. Conclusion: Patients with COVID-19 who were treated with Imfluna for 2 weeks had better comfort and fewer symptoms associated with the disease with no any drug side effects. © 2020. Open access.
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