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Ivermectin-Induced Clinical Improvement and Alleviation of Significant Symptoms of Covid-19 Outpatients: A Cross-Sectional Study Publisher



Niaee MS1 ; Zolghadr L2 ; Hosseinkhani Z3 ; Namdar P4 ; Allami A5 ; Amini F6 ; Varnaseri M6 ; Pourdast A7 ; Gheibi N8
Authors
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Authors Affiliations
  1. 1. Science and Technology Park, Qazvin, Iran
  2. 2. Department of Chemistry, Imam Khomeini International University, Qazvin, Iran
  3. 3. Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
  4. 4. Department of Surgery, Qazvin University of Medical Sciences, Qazvin, Iran
  5. 5. Department of Infectious Diseases, Clinical Research Development Unit, Bou Ali Sina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
  6. 6. Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran

Source: Iranian Journal of Science and Technology# Transaction A: Science Published:2022


Abstract

Although several drugs have been proposed and used to treat the COVID-19 virus, but recent clinical trials have concentrated on ivermectin. It appears that ivermectin can potentially act against COVID-19 and stop the development in its infancy. The purpose of this study was to determine the effect of ivermectin on the recovery of outpatients with COVID-19. In this cross-sectional study, we compared the symptoms reduction in COVID-19 disease in two groups of patients by administering ivermectin. A total of 347 mild outpatients in the Iranian provinces of Qazvin and Khuzestan with a confirmed PCR were enrolled. The symptoms of outpatients with COVID-19 were analyzed using SPSS (V23). In this cross-sectional study, the sex ratio was 0.64 (female/male: 37.9/59.8) and most patients were under 50 years old (72.8%). The results of this study demonstrated a significant decrease in several COVID-19 disease symptoms, including fever, chills, dyspnea, headache, cough, fatigue, and myalgia in the group administered ivermectin compared to the control group. In addition, the odds ratio of the above symptoms was significantly lower in patients who received ivermectin than in patients who did not receive the drug (OR = 0.16, 95% CI = 0.09, 0.27). © 2022, The Author(s), under exclusive licence to Shiraz University.
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