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Nanoparticle-Sirna: A Potential Strategy for Ovarian Cancer Therapy? Publisher Pubmed



Aghamiri S1 ; Mehrjardi KF2, 3 ; Shabani S4 ; Keshavarzfathi M3, 5 ; Kargar S6 ; Rezaei N7
Authors
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Authors Affiliations
  1. 1. Stud. Research Committee, Department of Medical Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19839-63113, Iran
  2. 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  3. 3. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, 1419733151, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  5. 5. Stud. Scientific Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  6. 6. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, 1417466191, Iran
  7. 7. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, 1419733151, Iran

Source: Nanomedicine Published:2019


Abstract

Ovarian cancer is one of the most common causes of mortality throughout the world. Unfortunately, chemotherapy has failed to cure advanced cancers developing multidrug resistance (MDR). Moreover, it has critical side effects because of nonspecific toxicity. Thanks to specific silencing of oncogenes and MDR-associated genes, nano-siRNA drugs can be a great help address the limitations of chemotherapy. Here, we review the current advances in nanoparticle-mediated siRNA delivery strategies such as polymeric- and lipid-based systems, rigid nanoparticles and nanoparticles coupled to specific ligand systems. Nanoparticle-based codelivery of anticancer drugs and siRNA targeting various mechanisms of MDR is a cutting-edge strategy for ovarian cancer therapy, which is completely discussed in this review. © 2019 Future Medicine Ltd.
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