Manufacturing and Characterizing of the Poly (Ε-Caprolactone)/Poly (N-Vinyl-2-Pyrrolidone) Core-Shell Nanofibers Loaded by Multi-Walled Carbon Nanotubes Coated by Polypyrrole Via Vapor Phase and Chemical Method and Its Application As an Electro-Responsive Anticancer Drug Delivery System Publisher



Nasari M¹ ; Semnani D¹ ; Amanpour S² Show Affiliations
Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2023

Abstract

The drug release systems are useful in controlling efficacy, improvement of function and reduction of side effects of drugs. Herein, Poly (ε-caprolactone) (PCL)/Poly (N-vinyl-2-pyrrolidone) (PVP) core-shell nanofibers loaded by multi-walled carbon nanotubes (MWCNTs) were produced. The surfaces of nanofibers were coated by polypyrrole (PPy) via vapor phase and chemical method. The chemical method was desirable according to SEM images and electrical conductivity of about 502.89 ± 45.25 S/m. Electrical stimulation was performed in the coated sample and the release of 5-fluorouracil (5FU) was investigated. Drug release of non-coated and coated samples without/with field application was investigated. The results exhibited the electric signal could be considered as a drug release control factor for coated samples with electrical field application. © 2022 Taylor & Francis Group, LLC.