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A Novel Bilayer Drug-Loaded Wound Dressing of Pvdf and Phb/Chitosan Nanofibers Applicable for Post-Surgical Ulcers Publisher



Amini F1 ; Semnani D1 ; Karbasi S2 ; Banitaba SN1
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2019


Abstract

A novel bilayer nanofibrous wound dressing, with enhanced mechanical properties is successfully fabricated. This membrane, consisted of polyvinylidenefluoride (PVDF) nanofibers for providing tensile strength and polyhydroxybutyrate/chitosan (PHB/CTS) nanofibers loaded with gentamicin with ability of controlled drug delivery, is a great choice for post-surgical ulcers. Mechanical properties showed dramatically improvement of tensile strength by addition of PVDF layer. Gentamycin release represented both an immediate and a sustained release of about 24 h and 1 week, respectively and release increment with increase of CTS ratio. Results also revealed that drug release in structures follow first order kinetic and Fickian release mechanism. © 2018, © 2018 Taylor & Francis.
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