Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Chemoprotection of Mnng-Initiated Gastric Cancer in Rats Using Iranian Propolis Pubmed



Alizadeh AM1 ; Afrouzan H2 ; Dinparastdjadid N3 ; Sawaya ACHF4 ; Azizian S1 ; Hemmati HR1 ; Mohagheghi MA1 ; Erfani S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Honeybee Department, Animal Sciences Research Institute Karaj, Iran
  3. 3. Malaria and Vector Research Group, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Department of Plant Biology, Institute of Biology, University of Campinas, UNICAMP, Campinas, 13083-970, SP, Brazil

Source: Archives of Iranian Medicine Published:2015


Abstract

Background: Iranian propolis is a natural product of honeybees that has significant and varied anti-cancer benefits. The present study was designed to investigate the protective effects of Iranian propolis on gastric tissue carcinogenesis in an animal model.; Method: Propolis samples were collected from Hamadan and Taleghan districts of Iran, followed by ultra performance liquid chromatography mass spectrometry analysis. Fifty-five rats were divided into three groups; control, Taleghan propolis and Hamadan propolis. All the animals received N-methyl-N-nitro-N-nitrosoguanidine (MNNG, 100 |jg/ml_) in drinking water ad libitum for 34 weeks. In the treated groups, nutrition with propolis was started two weeks before MNNG administration. At the end of the study, the entire gastrointestinal tract was scrutinized for tumors, and the rest of the body was assessed for metastatic deposits.; Results: Results indicated that the incidence and number of tumors were significantly decreased by propolis in comparison with the control group (P < 0.05). The nuclear/cytoplasmic ratio, epithelial stratification, nuclear dispolarity, structural abnormality, and Beta-catenin and Bcl-2 proteins expression were significantly reduced in the propolis group compared to the control group (P < 0.05). In addition, Bax protein expression was significantly increased in the propolis group in comparison with the control group (P < 0.05).; Conclusion: The present study demonstrated the potential chemoprotective effects of the Iranian propolis against gastric cancer in a typical animal model. The results provide evidence for the hypothesis that Iranian propolis may exert a chemoprotective effect on MNNG- initiated gastric cancer through inhibition of cell proliferation and apoptosis induction. © 2015, Academy of Medical Sciences of I.R. Iran. All rights reserved.
Related Docs
1. Apoptotic and Proliferative Activity of Mouse Gastric Mucosa Following Oral Administration of Fumonisin B1, Iranian Journal of Basic Medical Sciences (2015)
2. Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy, BioMed Research International (2015)
3. Effects of Exercise Training Together With Tamoxifen in Reducing Mammary Tumor Burden in Mice: Possible Underlying Pathway of Mir-21, European Journal of Pharmacology (2015)
4. Propolis Efficacy on Sars-Cov Viruses: A Review on Antimicrobial Activities and Molecular Simulations, Environmental Science and Pollution Research (2022)
5. Microrna-206, Let-7A and Microrna-21 Pathways Involved in the Anti-Angiogenesis Effects of the Interval Exercise Training and Hormone Therapy in Breast Cancer, Life Sciences (2016)
Experts (# of related papers)
View all Related Experts
Alimohammad Alizadeh (4)
Shaban Alizadeh (1)