In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent

In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent Publisher

Zare N¹ ; Bandarian F² ; Esfahani EN² ; Larijani B³ ; Mahdavi M³ ; Mohammadikhanaposhtani M⁴ ; Najafzadehvarzi H⁴

Show Affiliations

1. Faculty of Pharmacy, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
2. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, University of Medical Sciences, Tehran, Iran
3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2023

Abstract

Background: The in vivo assessment of a novel compound is a pivotal step in the development of a new drug. In this study, we selected 1-(2-bromophenyl)-1,11-dihydro-3H-benzo[h]pyrano[3,2-c]quinoline-3,12(2H)-dione (2-BDBPQD), identified as an exemplary α-glucosidase inhibitor in preliminary in vitro assays, for further evaluation in an in vivo anti-diabetic context. Methods: The in vivo anti-diabetic effect of 2-BDBPQD was assessed using a streptozotocin (STZ)-induced diabetic Wistar rat model. Recognizing the relevance of lipid factors in diabetes, we also investigated the impact of this compound on the lipid profile of diabetic Wistar rats. In silico studies, encompassing docking studies and pharmacokinetic predictions of 2-BDBPQD, were conducted. Results: The results obtained indicated a significant reduction in blood glucose levels with 2-BDBPQD treatment compared to acarbose. However, no significant effects on the lipid profile were observed. In silico studies revealed that 2-BDBPQD interacted with key residues in the α-glucosidase active site and exhibited favorable pharmacokinetic properties. Conclusion: In summary, the study demonstrated the in vivo anti-hyperglycemic activity of 2-BDBPQD. Nevertheless, further in vivo evaluations are recommended to comprehensively assess its potential as a new drug for the treatment of diabetes. © 2023, The Author(s), under exclusive licence to Tehran University of Medical Sciences.

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Style	Citing Format
MLA	Zare N, et al.. "In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent." Journal of Diabetes and Metabolic Disorders, vol. , no. , 2023, pp. -.
APA	Zare N, Bandarian F, Esfahani EN, Larijani B, Mahdavi M, Mohammadikhanaposhtani M, Najafzadehvarzi H (2023). In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent. Journal of Diabetes and Metabolic Disorders, (), -.
Chicago	Zare N, Bandarian F, Esfahani EN, Larijani B, Mahdavi M, Mohammadikhanaposhtani M, Najafzadehvarzi H. "In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent." Journal of Diabetes and Metabolic Disorders , no. (2023): -.
Harvard	Zare N et al. (2023) 'In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent', Journal of Diabetes and Metabolic Disorders, (), pp. -.
Vancouver	Zare N, Bandarian F, Esfahani EN, Larijani B, Mahdavi M, Mohammadikhanaposhtani M, et al.. In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent. Journal of Diabetes and Metabolic Disorders. 2023;():-.
BibTex	@article{ author = {Zare N and Bandarian F and Esfahani EN and Larijani B and Mahdavi M and Mohammadikhanaposhtani M and Najafzadehvarzi H}, title = {In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent}, journal = {Journal of Diabetes and Metabolic Disorders}, volume = {}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Zare N AU - Bandarian F AU - Esfahani EN AU - Larijani B AU - Mahdavi M AU - Mohammadikhanaposhtani M AU - Najafzadehvarzi H TI - In Vivo and in Silico Evaluations of a Synthetic Pyrano[3,2-C]Quinoline Derivative As a Potent Anti-Diabetic Agent JO - Journal of Diabetes and Metabolic Disorders VL - IS - SP - EP - PY - 2023 ER -

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