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Heterocyclic Compounds: Effective Α-Amylase and Α-Glucosidase Inhibitors Publisher Pubmed



Saeedi M1, 2 ; Hadjiakhondi A2, 3 ; Nabavi SM4 ; Manayi A2
Authors
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Authors Affiliations
  1. 1. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Current Topics in Medicinal Chemistry Published:2017


Abstract

Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently, it has emerged as an important and global health problem with long-term complications and high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes. Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy and α-Gls and were found to be versatile tools for the development of novel antidiabetic agents. © 2017 Bentham Science Publishers.
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