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Heterocyclic Compounds: Effective Α-Amylase and Α-Glucosidase Inhibitors Publisher Pubmed



Saeedi M1, 2 ; Hadjiakhondi A2, 3 ; Nabavi SM4 ; Manayi A2
Authors

Source: Current Topics in Medicinal Chemistry Published:2017


Abstract

Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently, it has emerged as an important and global health problem with long-term complications and high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes. Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy and α-Gls and were found to be versatile tools for the development of novel antidiabetic agents. © 2017 Bentham Science Publishers.
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