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Applications of Mesenchymal Stem Cells in Ocular Surface Diseases: Sources and Routes of Delivery Publisher Pubmed



Soleimani M1, 2 ; Masoumi A2 ; Momenaei B2 ; Cheraqpour K2 ; Koganti R1 ; Chang AY1 ; Ghassemi M1 ; Djalilian AR1
Authors
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Authors Affiliations
  1. 1. Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States
  2. 2. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Expert Opinion on Biological Therapy Published:2023


Abstract

Introduction: Mesenchymal stem cells (MSCs) are novel, promising agents for treating ocular surface disorders. MSCs can be isolated from several tissues and delivered by local or systemic routes. They produce several trophic factors and cytokines, which affect immunomodulatory, transdifferentiating, angiogenic, and pro-survival pathways in their local microenvironment via paracrine secretion. Moreover, they exert their therapeutic effect through a contact-dependent manner. Areas covered: In this review, we discuss the characteristics, sources, delivery methods, and applications of MSCs in ocular surface disorders. We also explore the potential application of MSCs to inhibit senescence at the ocular surface. Expert opinion: Therapeutic application of MSCs in ocular surface disorders are currently under investigation. One major research area is corneal epitheliopathies, including chemical or thermal burns, limbal stem cell deficiency, neurotrophic keratopathy, and infectious keratitis. MSCs can promote corneal epithelial repair and prevent visually devastating sequelae of non-healing wounds. However, the optimal dosages and delivery routes have yet to be determined and further clinical trials are needed to address these fundamental questions. © 2023 Informa UK Limited, trading as Taylor & Francis Group.
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