Tehran University of Medical Sciences

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Metastatic Melanoma (Secondary Malignancy) After Recovery From Acute Lymphoblastic Leukemia in a 10-Year-Old Girl: A Case Report Publisher



Yousofian S1 ; Mirialiabad G2 ; Rostami T3 ; Mehrazma M4 ; Nematollahi P5
Authors
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Authors Affiliations
  1. 1. Children and Adolescent Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  3. 3. Tehran University of Medical Sciences and Health Services, Tehran, Iran
  4. 4. Oncopathology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Pediatric Hematology and Oncology Published:2019


Abstract

Acute lymphoblastic leukemia is the most common malignancy in children with a 5-year survival rate, accounting for 80% of cases. Melanoma is rare in children and has been reported as a sporadically occurring secondary malignant neoplasm in children with acute lymphoblastic leukemia. This study presented a 10-year-old Iranian child with pre-B-cell acute lymphoblastic leukemia that was diagnosed at age 6. She was fully recovered after 2 years of treatment. One year and six months after cessation of treatment, she was referred with a 1x2 cm mass in her right parietal region of scalp. Biopsy of the lesion confirmed the diagnosis of malignant melanoma. Computed tomography scan of the chest and abdomen also confirmed extensive liver metastasis which was corroborated by liver biopsy. Bone scan also revealed bone metastases. Early diagnosis and treatment of these tumors is extremely important and these patients should be closely monitored and undergo regular physical examination. © 2019. All Rights Reserved.