The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy

The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy Publisher Pubmed

Rahmanian N^{1, 2} ; Hosseinimehr SJ² ; Khalaj A³

Show Affiliations

1. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Biomedical Science Published:2016

Abstract

Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resulted in apoptosis in cancer cells, it also stimulates tumor cell re-population that leads to reduce the effectiveness of the radiation therapy. This review describes the mechanisms for paradox role of caspase cascade in cancer therapy and discusses the logical and practical strategies for improvement the therapeutic index of radiotherapy through enhancement of radiosensitivity and decreasing the rate of tumor recurrence. © 2016 The Author(s)

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Style	Citing Format
MLA	Rahmanian N, Hosseinimehr SJ, Khalaj A. "The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy." Journal of Biomedical Science, vol. 23, no. 1, 2016, pp. 1-13.
APA	Rahmanian N, Hosseinimehr SJ, Khalaj A (2016). The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy. Journal of Biomedical Science, 23(1), 1-13.
Chicago	Rahmanian N, Hosseinimehr SJ, Khalaj A. "The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy." Journal of Biomedical Science 23, no. 1 (2016): 1-13.
Harvard	Rahmanian N, Hosseinimehr SJ, Khalaj A (2016) 'The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy', Journal of Biomedical Science, 23(1), pp. 1-13.
Vancouver	Rahmanian N, Hosseinimehr SJ, Khalaj A. The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy. Journal of Biomedical Science. 2016;23(1):1-13.
BibTex	@article{ author = {Rahmanian N and Hosseinimehr SJ and Khalaj A}, title = {The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy}, journal = {Journal of Biomedical Science}, volume = {23}, number = {1}, pages = {1-13}, year = {2016} }
RIS	TY - JOUR AU - Rahmanian N AU - Hosseinimehr SJ AU - Khalaj A TI - The Paradox Role of Caspase Cascade in Ionizing Radiation Therapy JO - Journal of Biomedical Science VL - 23 IS - 1 SP - 1 EP - 13 PY - 2016 ER -

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