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The Effect of Crocin Supplementation on Lipid Concentrations and Fasting Blood Glucose: A Systematic Review and Meta-Analysis and Meta-Regression of Randomized Controlled Trials Publisher Pubmed



Naserizadeh SK1 ; Taherifard MH2 ; Shekari M3 ; Mesrkanlou HA4 ; Asbaghi O5 ; Nazarian B5 ; Khosroshahi MZ5 ; Heydarpour F6
Authors
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Authors Affiliations
  1. 1. Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Physical Education, East Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Nutrition, Faculty of Health, Qazvin University of Medical Sciences Qazvin, Iran
  4. 4. Faculty Of Public Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
  6. 6. Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: Complementary Therapies in Medicine Published:2020


Abstract

Objective: This meta-analysis aimed to assess the effects of crocin supplementation on fasting blood glucose (FBG) and lipid profile levels in clinical trial studies. Design: A systematic literature search was performed in PubMed, Scopus, Embase, Web of Science, and the Cochrane Library databases for clinical trials published from the beginning up to November 2019. Of the 547 papers identified from all searched databases, eight eligible studies with nine effect sizes have all needed criteria for inclusion in this meta-analysis. Results: Results of the pooled random-effect size analysis showed just a significant decreasing effect of crocin supplementation on FBG (WMD: -6.52 mg/l, 95 % CI, -11.96, -1.08; p = 0.019) and TC (WMD: -4.64 mg/l, 95 % CI, -8.19, -1.09; p = 0.010). Crocin supplements did not have any significant effect on serum TG (p = 0.144) levels, LDL-C (p = 0.161), and HDL-C (p = 0.872) levels. Results showed that crocin supplementation could beneficially have effect on TG level only when trial duration less than 12 weeks and LDL-C levels in trials that used high dose intervention and trials that conducted on subjects with metabolic disorders. However, crocin supplementation did not significantly change FBG in trials that used low dose intervention. Meta-regression analysis indicated a linear relationship between the duration of intervention and significant change in FBG (p = 0.019). Conclusion: Results of this systematic review and meta-analysis study have shown that crocin supplementation can decrease significantly FBS and TC without any beneficial effects on TG, LDL-C, and HDL-C levels. © 2020
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