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Therapeutic Potential and Mechanisms of Curcumin in Cardiovascular Diseases: A Comprehensive Review Publisher Pubmed



Nourmohammad A ; Zonoubi N ; Ghavamikia N
Authors

Source: Phytochemical Analysis Published:2026


Abstract

Background: Curcumin is recognized for its therapeutic potential in cardiovascular diseases (CVDs), with effects on cardiomyocytes, vascular function, and hypertrophy. Objective: This review aims to evaluate curcumin's therapeutic effects, mechanisms of action, and safety in CVD management. Methods: A comprehensive review of existing literature was conducted, focusing on curcumin's impact on ischemia, hypoxia, myocardial hypertrophy, fibrosis, and endothelial function. Results: Curcumin protects cardiomyocytes, enhances vascular function, and exhibits inconsistent effects on cholesterol accumulation in macrophages. Conclusion: While curcumin shows promise as a complementary agent in CVD management, further research, particularly large-scale clinical trials, is essential to validate its efficacy and safety. © 2026 John Wiley & Sons Ltd.
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