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Rapid and Sensitive Detection of Hydrogen Peroxide in Milk by Enzyme-Free Electrochemiluminescence Sensor Based on a Polypyrrole-Cerium Oxide Nanocomposite Publisher



Karimi A1 ; Husain SW1 ; Hosseini M2, 3 ; Azar PA1 ; Ganjali MR4, 5
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Islamic Azad University, Science and Research Branch, Tehran, Iran
  2. 2. Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran
  3. 3. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  5. 5. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Sensors and Actuators# B: Chemical Published:2018


Abstract

An H2O2 electrochemiluminescence (ECL) sensor with a very low detection limit has been developed using a hybrid of polypyrrole-dodesylbenzen sulfate-cerium oxide nanocomposite (PPy-DBS-CeO2) on a Pt electrode. The incorporation of the CeO2 nanoparticles in the polymeric matrix of the composite enhanced the ECL signal. Under optimal conditions, the signal and the logarithm of H2O2 concentration showed a linear relationship from 5.0 × 10−16 to 5.0 × 10−5 M (R2 = 0.9922) and a very low detection limit of 1.2 × 10−16 M was observed. The sensor revealed good reproducibility and stability and was found applicable to the detection of H2O2 in water and milk samples. © 2018 Elsevier B.V.