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Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine Publisher Pubmed



Rahmati M1, 2, 3 ; Pennisi CP4 ; Mobasheri A5, 6, 7, 8, 9 ; Mozafari M1, 2, 3
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran
  2. 2. Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  3. 3. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  4. 4. Laboratory for Stem Cell Research, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark
  5. 5. The D-BOARD FP7 Consortium, Surrey, United Kingdom
  6. 6. The APPROACH IMI Consortium, Surrey, United Kingdom
  7. 7. Faculty of Health and Medical Sciences, University of Surrey, Surrey, United Kingdom
  8. 8. Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Queen’s Medical Centre, Nottingham, United Kingdom
  9. 9. Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania

Source: Advances in Experimental Medicine and Biology Published:2018


Abstract

Stem cell-based therapies, harnessing the ability of stem cells to regenerate damaged or diseased tissues, are under wide-ranging consideration for regenerative medicine applications. However, limitations concerning poor cell persistence and engraftment upon cell transplantation still remain. During the recent years, several types of biomaterials have been investigated to control the fate of the transplanted stem cells, aiming to increase their therapeutic efficiency. In the present chapter we focus on the general properties of some of these biomaterials, which include polymers, ceramics, and nano-biomaterials. In the first part of the chapter, a brief explanation about stem cell biology, sources, and their microenvironment is provided. The second part of the chapter presents some of the most recent studies investigating different types of biomaterials and approaches that aim to mimic the stem cell microenvironment for a more precise control of the stem cell fate. © Springer International Publishing AG, part of Springer Nature 2018.
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