Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification

Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification Publisher Pubmed

Zarei M^{1, 7} ; Shabani Dargah M² ; Hasanzadeh Azar M³ ; Alizadeh R¹ ; Mahdavi FS⁴ ; Sayedain SS¹ ; Kaviani A⁵ ; Asadollahi M¹ ; Azami M^{6, 7, 8} ; Beheshtizadeh N^{6, 7}

Show Affiliations

1. Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
2. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
3. Department of Engineering Physics, McMaster University, Hamilton, Canada
4. Department of Biotechnology Engineering, College of Science, University of Tehran, Tehran, Iran
5. Polymeric Materials Research Group (PMRG), Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran
6. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
7. Regenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran
8. Joint Reconstruction Research Center (JRRC), Tehran University of Medical Sciences, Tehran, Iran

Source: Scientific Reports Published:2023

Abstract

The mechanical and biological properties of polylactic acid (PLA) need to be further improved in order to be used for bone tissue engineering (BTE). Utilizing a material extrusion technique, three-dimensional (3D) PLA-Ti6Al4V (Ti64) scaffolds with open pores and interconnected channels were successfully fabricated. In spite of the fact that the glass transition temperature of PLA increased with the addition of Ti64, the melting and crystallization temperatures as well as the thermal stability of filaments decreased slightly. However, the addition of 3–6 wt% Ti64 enhanced the mechanical properties of PLA, increasing the ultimate compressive strength and compressive modulus of PLA-3Ti64 to 49.9 MPa and 1.9 GPa, respectively. Additionally, the flowability evaluations revealed that all composite filaments met the print requirements. During the plasma treatment of scaffolds, not only was the root-mean-square (Rq) of PLA (1.8 nm) increased to 60 nm, but also its contact angle (90.4°) significantly decreased to (46.9°). FTIR analysis confirmed the higher hydrophilicity as oxygen-containing groups became more intense. By virtue of the outstanding role of plasma treatment as well as Ti64 addition, a marked improvement was observed in Wharton's jelly mesenchymal stem cell attachment, proliferation (4′,6-diamidino-2-phenylindole staining), and differentiation (Alkaline phosphatase and Alizarin Red S staining). Based on these results, it appears that the fabricated scaffolds have potential applications in BTE. © 2023, The Author(s).

2. Recent Advances on 3D-Printed Pcl-Based Composite Scaffolds for Bone Tissue Engineering, Frontiers in Bioengineering and Biotechnology (2023)

3. Applying Extrusion-Based 3D Printing Technique Accelerates Fabricating Complex Biphasic Calcium Phosphate-Based Scaffolds for Bone Tissue Regeneration, Journal of Advanced Research (2022)

4. 3D Printing of Complicated Gelma-Coated Alginate/Tri-Calcium Silicate Scaffold for Accelerated Bone Regeneration, International Journal of Biological Macromolecules (2023)

5. State of the Art Review on Design and Manufacture of Hybrid Biomedical Materials: Hip and Knee Prostheses, Proceedings of the Institution of Mechanical Engineers# Part H: Journal of Engineering in Medicine (2017)

6. In Vitro Tribological Behavior and Corrosion Resistance of Sio2/Tio2/Zro2 Coatings Formed on the Tantalum Substrate Using Plasma Electrolytic Oxidation for Orthopedic Implant Applications, Materials Chemistry and Physics (2023)

7. Could We Use Metallic Wood for Bone Tissue Engineering Applications?, Results in Engineering (2023)

Experts (# of related papers)

Mahmoud Azami (4)

Nasrin Lotfibakhshaiesh (1)

Style	Citing Format
MLA	Zarei M, et al.. "Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification." Scientific Reports, vol. 13, no. 1, 2023, pp. -.
APA	Zarei M, Shabani Dargah M, Hasanzadeh Azar M, Alizadeh R, Mahdavi FS, Sayedain SS, Kaviani A, Asadollahi M, Azami M, Beheshtizadeh N (2023). Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification. Scientific Reports, 13(1), -.
Chicago	Zarei M, Shabani Dargah M, Hasanzadeh Azar M, Alizadeh R, Mahdavi FS, Sayedain SS, Kaviani A, Asadollahi M, Azami M, Beheshtizadeh N. "Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification." Scientific Reports 13, no. 1 (2023): -.
Harvard	Zarei M et al. (2023) 'Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification', Scientific Reports, 13(1), pp. -.
Vancouver	Zarei M, Shabani Dargah M, Hasanzadeh Azar M, Alizadeh R, Mahdavi FS, Sayedain SS, et al.. Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification. Scientific Reports. 2023;13(1):-.
BibTex	@article{ author = {Zarei M and Shabani Dargah M and Hasanzadeh Azar M and Alizadeh R and Mahdavi FS and Sayedain SS and Kaviani A and Asadollahi M and Azami M and Beheshtizadeh N}, title = {Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification}, journal = {Scientific Reports}, volume = {13}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Zarei M AU - Shabani Dargah M AU - Hasanzadeh Azar M AU - Alizadeh R AU - Mahdavi FS AU - Sayedain SS AU - Kaviani A AU - Asadollahi M AU - Azami M AU - Beheshtizadeh N TI - Enhanced Bone Tissue Regeneration Using a 3D-Printed Poly(Lactic Acid)/Ti6al4v Composite Scaffold With Plasma Treatment Modification JO - Scientific Reports VL - 13 IS - 1 SP - EP - PY - 2023 ER -

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