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Design and Development of a Dedicated Portable Gamma Camera System for Intra-Operative Imaging Publisher Pubmed



Kaviani S1 ; Zeraatkar N1 ; Sajedi S1 ; Akbarzadeh A1 ; Gorjizadeh N1, 2 ; Farahani MH1 ; Teimourian B1 ; Ghafarian P3, 4 ; Sabet H5 ; Ay MR1, 2
Authors
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Authors Affiliations
  1. 1. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Chronic Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. PET/CT and Cyclotron Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Massachusetts General Hospital, Harvard Medical School, Boston, United States

Source: Physica Medica Published:2016


Abstract

Purpose We developed a high performance portable gamma camera platform dedicated to identification of sentinel lymph nodes (SLNs) and radio-guided surgery for cancer patients. In this work, we present the performance characteristics of SURGEOSIGHT-I, the first version of this platform that can intra-operatively provide high-resolution images of the surveyed areas. Methods At the heart of this camera, there is a 43 × 43 array of pixelated sodium-activated cesium iodide (CsI(Na)) scintillation crystal with 1 × 1 mm2 pixel size and 5 mm thickness coupled to a Hamamatsu H8500 flat-panel multi-anode (64 channels) photomultiplier tube. The probe is equipped with a hexagonal parallel-hole lead collimator with 1.2 mm holes. The detector, collimator, and the associated front-end electronics are encapsulated in a common housing referred to as head. Results Our results show a count rate of ∼41 kcps for 20% count loss. The extrinsic energy resolution was measured as 20.6% at 140 keV. The spatial resolution and the sensitivity of the system on the collimator surface was measured as 2.2 mm and 142 cps/MBq, respectively. In addition, the integral and differential uniformity, after uniformity correction, in useful field-of-view (UFOV) were measured 4.5% and 4.6%, respectively. Conclusions This system can be used for a number of clinical applications including SLN biopsy and radiopharmaceutical-guided surgery. © 2016 Associazione Italiana di Fisica Medica