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A Review on the Role of Mir-149-5P in the Carcinogenesis Publisher Pubmed



Ghafourifard S1 ; Khoshbakht T2 ; Hussen BM3 ; Kadkhoda S4 ; Taheri M5 ; Tafrishinejad A6
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 16666-63111, Iran
  2. 2. Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 16666-63111, Iran
  3. 3. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, 44001, Iraq
  4. 4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 16666-63111, Iran
  5. 5. Institute of Human Genetics, Jena University Hospital, Jena, 07740, Germany
  6. 6. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 16666-63111, Iran

Source: International Journal of Molecular Sciences Published:2022


Abstract

miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the “guide” and the sister “passenger” strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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