Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Microrna a New Gate in Cancer and Human Disease: A Review Publisher



Chalbatani GM1 ; Mahmoodzadeh H1 ; Gharagozlou E1 ; Dana H2 ; Zeinalinia E2 ; Rezaeian O3 ; Memari F1 ; Ardaneh M3 ; Meghdadi S3 ; Pilvar P2 ; Rad N4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
  2. 2. Department of Biology, Islamic Azad University, Damghan Branch, Damghan, Iran
  3. 3. Department of Biology, Nour Danesh Institute of Higher Education, Isfahan, Iran
  4. 4. Islamic Azad University, Pharmaceutical sciences branch, Tehran, Iran

Source: Journal of Biological Sciences Published:2017


Abstract

MicroRNAs are small noncoding RNAs with lengths of 21-22 nucleotides that participate in post-transcriptional control of gene expression. According to recent studies, 2588 microRNAs have been detected and the list is growing. Furthermore, microRNA (miRNA) plays a major role in regulating biological processes and miRNA in relation to many diseases including cancer. The deregulation connection between miRNA and cancer was discovered in 2002. Today, even more information about the main role that miRNA plays in cancer development has been uncovered, however, there is still a long way to go to understand the functions of all the microRNAs in eukaryotes. In this review, briefly explained miRNA biogenesis and discuss the roles that miRNAs play in cancer development. Finally, discussed how miRNAs can be used as biomarkers and as a new therapeutic approach in cancer. © 2017 Ghanbar Mahmoodi Chalbatani et al.
Related Docs
View other Related Docs
1. Micrornas As Biomarkers for Early Diagnosis, Targeting and Prognosis of Prostate Cancer, Pathology Research and Practice (2023)
2. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
3. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)
4. Lung Cancer and Mirnas: A Possible Remedy for Anti-Metastatic, Therapeutic and Diagnostic Applications, Expert Review of Respiratory Medicine (2017)
5. Differential Role of Micrornas in Prognosis, Diagnosis, and Therapy of Ovarian Cancer, Biomedicine and Pharmacotherapy (2016)
6. The Role of Oncomirs in the Pathogenesis and Treatment of Breast Cancer, Biomedicine and Pharmacotherapy (2016)
7. Microrna-155 and Its Exosomal Form: Small Pieces in the Gastrointestinal Cancers Puzzle, Cell Biology and Toxicology (2024)
8. Circulating Micrornas in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers, Current Pharmaceutical Design (2016)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (7)
Nima Rezaei (2)
Other Related Docs
9. Is Mir-144 an Effective Inhibitor of Pten Mrna: A Controversy in Breast Cancer, In Vitro Cellular and Developmental Biology - Animal (2018)
10. The Microrna Let-7 and Its Exosomal Form: Epigenetic Regulators of Gynecological Cancers, Cell Biology and Toxicology (2024)
11. The Effect of Prednisolone on Mir 15A and Mir16-1 Expression Levels and Apoptosis in Acute Lymphoblastic Leukemia Cell Line: Ccrf-Cem, Drug Research (2016)
12. Critical Considerations for Investigating Micrornas During Tumorigenesis: A Case Study in Conceptual and Contextual Nuances of Mir-211-5P in Melanoma, Epigenomes (2023)
13. Prostate Cancer and Noncoding Rnas: A Focus on Mirnas, Lncrnas, and Circrnas, Prostate Cancer: Molecular Events and Therapeutic Modalities (2024)
14. Effects of Micro Rnas and Their Targets in Periodontal Diseases, Infectious Disorders - Drug Targets (2018)
15. Recent Advances on High-Efficiency of Micrornas in Different Types of Lung Cancer: A Comprehensive Review, Cancer Cell International (2023)
16. Overexpression of Microrna-16 Declines Cellular Growth, Proliferation and Induces Apoptosis in Human Breast Cancer Cells, In Vitro Cellular and Developmental Biology - Animal (2015)
17. Downregulation of Plasma Mir-142-3P and Mir-26A-5P in Patients With Colorectal Carcinoma, International Journal of Cancer Management (2015)
18. Environmental Toxicants, Incidence of Degenerative Diseases, and Therapies From the Epigenetic Point of View, Archives of Toxicology (2017)
19. Overexpression of Ddit4 and Tptep1 Are Associated With Metastasis and Advanced Stages in Colorectal Cancer Patients: A Study Utilizing Bioinformatics Prediction and Experimental Validation, Cancer Cell International (2021)
20. Bioinformatics Prioritization of Snps Perturbing Microrna Regulation of Hematological Malignancy-Implicated Genes, Genomics (2015)
21. To Be or Not to Be: Navigating the Influence of Micrornas on Cervical Cancer Cell Death, Cancer Cell International (2025)
22. Liquid Biopsy in Thyroid Cancer: New Insight, International Journal of Hematology-Oncology and Stem Cell Research (2018)
23. A Novel Panel of Blood-Based Micrornas Capable of Discrimination Between Benign Breast Disease and Breast Cancer at Early Stages, RNA Biology (2021)
24. Experimental Validation of Mir-4443, Mir-572, and Mir-150-5P in Serum and Tissue of Breast Cancer Patients As a Potential Diagnostic Biomarker: A Study Based on Bioinformatics Prediction, Biochemical Genetics (2025)
25. An Innovative Paradigm of Methods in Micrornas Detection: Highlighting Dnazymes, the Illuminators, Biosensors and Bioelectronics (2018)
26. Lung Cancer-Associated Brain Metastasis: Molecular Mechanisms and Therapeutic Options, Cellular Oncology (2017)
27. Microrna Expression Levels and Histopathological Features of Colorectal Cancer, Journal of Gastrointestinal Cancer (2019)
28. A Universal Ratiometric Method for Micro-Rna Detection Based on the Ratio of Electrochemical/Electrochemiluminescence Signal, and Toehold-Mediated Strand Displacement Amplification, Analytica Chimica Acta (2023)
29. Exosomes and Non-Coding Rnas: Exploring Their Roles in Human Myocardial Dysfunction, Biomedicine and Pharmacotherapy (2025)
30. Extracellular Microrna Profiling in Human Follicular Fluid: New Biomarkers in Female Reproductive Potential, Journal of Assisted Reproduction and Genetics (2020)
31. The Role of Micrornas in the Viral Infections, Current Pharmaceutical Design (2018)
32. Circulating Micrornas As Predictive Biomarkers of Coronary Artery Diseases in Type 2 Diabetes Patients, Journal of Clinical Laboratory Analysis (2022)
33. Pathogenic Role of Exosomes and Micrornas in Hpv-Mediated Inflammation and Cervical Cancer: A Review, International Journal of Cancer (2020)
34. Effects of Micrornas and Long Non-Coding Rnas on Chemotherapy Response in Glioma, Epigenomics (2022)
35. Microrna-Based Linkage Between Aging and Cancer: From Epigenetics View Point, Cell Journal (2016)
36. Recent Advances in the Roles of Exosomal Micrornas (Exomirs) In Hematologic Neoplasms: Pathogenesis, Diagnosis, and Treatment, Cell Communication and Signaling (2023)
37. Expression Pattern of Key Micrornas in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase, International Journal of Laboratory Hematology (2015)
38. Circulating Micrornas As Diagnostic and Therapeutic Biomarkers in Gastric and Esophageal Cancers, Journal of Cellular Physiology (2018)
39. Emerging Role of Micrornas As Liquid Biopsy Biomarkers in Lung Cancer: A Review, Acta Medica Iranica (2021)
40. The Emerging Role of Exosomal Mirnas As a Diagnostic and Therapeutic Biomarker in Mycobacterium Tuberculosis Infection, Molecular Medicine (2021)
41. Non-Coding Rnas As Potential Therapeutic Targets for Receptor Tyrosine Kinase Signaling in Solid Tumors: Current Status and Future Directions, Cancer Cell International (2024)
42. Down-Regulation of Mir-122 After Transplantation of Mesenchymal Stem Cells in Acute Liver Failure in Mice Model, Biologicals (2019)
43. Cancer Genetics at a Glance: The Comprehensive Insights, Cancer Genetics and Psychotherapy (2017)
44. Hydrogel-Mediated Delivery of Microrna-92A Inhibitor Polyplex Nanoparticles Induces Localized Angiogenesis, Angiogenesis (2021)
45. Microrna in Alzheimer's Disease Revisited: Implications for Major Neuropathological Mechanisms, Reviews in the Neurosciences (2018)
46. Early Diagnosis of Oral Squamous Cell Carcinoma (Oscc) by Mir-138 and Mir-424-5P Expression As a Cancer Marker, Asian Pacific Journal of Cancer Prevention (2021)
47. Regulation of Tumor Angiogenesis by Micrornas: State of the Art, Journal of Cellular Physiology (2019)
48. Simultaneous Disruption of Circulating Mir-21 and Cytotoxic T Lymphocytes (Ctls): Prospective Diagnostic and Prognostic Markers for Esophageal Squamous Cell Carcinoma (Escc), Journal of Clinical Laboratory Analysis (2022)
49. Effect of a High-Intensity Interval Training on Serum Microrna Levels in Women With Breast Cancer Undergoing Hormone Therapy. a Single-Blind Randomized Trial, Annals of Physical and Rehabilitation Medicine (2019)
50. Non-Coding Rnas: Emerging Contributors to Chemoresistance in Chronic Myeloid Leukemia, Leukemia Research Reports (2025)