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Personalized Cancer Vaccine Publisher



Keshavarzfathi M1, 2, 3 ; Rezaei N3, 4, 5
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Vaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Published:2019


Abstract

Personalized medicine is going ahead toward clinical utilization. Due to the recent advances in the “omic” technologies, including genomic studies, the use of individualized approaches has progressed in various diseases including cancer. Individualization has also entered into the field of cancer immunotherapy. Seeking for and selecting the immunogenic neoantigens, which are personalized and unique tumor antigens caused by somatic mutations, is of interest to design specific immunotherapies including vaccines. Recent achievements have been yielded in the clinical trials evaluating synthetic long peptide and poly-neo-epitope RNA vaccines for improvement of disease-free survival in patients at high risk of melanoma recurrence. Hereby, we will review the application of personalized medicine and the related clinical trials in the field of immunotherapy with cancer vaccines. © 2019 Nima Rezaei and Mahsa Keshavarz-Fathi Published by Elsevier Ltd. All rights reserved.
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