Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparison of Cytotoxic Activity of Herbal Extracts on the Most Commonly Used Breast Cancer Cell Lines (Mcf7 and Skbr3): A Systematic Review Publisher



Dehghannayeri N1 ; Darvishi M2 ; Mashati P2 ; Rezapourkalkhoran M3 ; Rezaiefard M3 ; Younesian S4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Childern`s Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran
  4. 4. Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Research in Pharmacy Published:2020


Abstract

Herbal drug development is considered as an imperative part of complementary and alternative medicine. Bioactive compounds of botanical sources represent potential anti-cancer agents for modern therapeutics. Primary in vitro data of herb extracts’ effects against cancer cell lines could be considered as indicators of potential toxicity to reduce the number of in vivo experiments. This study aims to review the findings of published articles concerning the in vitro efficacy of herbal extracts against breast cancer cell lines (MCF7 and SKBR3). In vitro studies of herbal extracts published until July 2018 were included in this review. Totally, nine extracts with IC50<4 exhibited the most inhibitory effect on breast cancer cell lines. This investigation has highlighted the fact that plant extracts have the potential to act as promising anticancer agents, making them appropriate components to be applied for chemoprevention or cancer treatment in case the researchers would find the right plant, the right solvent and the right fraction for the right disease. © 2020 Marmara University Press.
Related Docs
1. The Phenolic Components Extracted From Mulberry Fruits As Bioactive Compounds Against Cancer: A Review, Phytotherapy Research (2023)
2. Quantification of Flavonoids in Alpinia Officinarum Hance. Via Hplc and Evaluation of Its Cytotoxicity on Human Prostate Carcinoma (Lncap) and Breast Carcinoma (Mcf-7) Cells, Anti-Cancer Agents in Medicinal Chemistry (2022)
3. In Vitro Anticancer Activity of Scrophularia Amplexicaulis Extracts on Mcf-7 and Wehi-164 Cell Line, EXCLI Journal (2020)
4. Suberosin Attenuates the Proliferation of Mcf-7 Breast Cancer Cells in Combination With Radiotherapy or Hyperthermia, Current Drug Research Reviews (2021)
5. Cytotoxic, Necrotic, Apoptotic, and Autophagic Properties of Venom Sac Extract of Vespa Orientalis in T47d and Mcf10a Breast Cell Lines, Toxin Reviews (2023)
Experts (# of related papers)
Javad Rafinejad (1)
Mohammadhadi Dehghani Tafti (1)