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The Expression of Microrna-155 (Mir-155) and Carcinoembryonic Antigen Messenger Rna (Cea Mrna) in Peripheral Blood of Patients With Oral Squamous Cell Carcinomas (Oscc) Publisher



Narimani A1 ; Hosseini F2 ; Bahrami N3 ; Mohamadnia A4
Authors
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Authors Affiliations
  1. 1. Department of Cell and Molecular Biology, School of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Microbiology, School of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran
  3. 3. Craniomaxillofacial Research Center AND Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) AND Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Isfahan Medical School Published:2019


Abstract

Background: Oral squamous cell carcinoma (OSCC) accounts for about 90% of all malignant oral tumors, and is often diagnosed in advanced stages. In this study, changes in the expression of microRNA-155 (miR-155) and carcinoembryonic antigen messenger RNA (CEA mRNA) in peripheral blood of patients with oral cancer were investigated. Methods: In this study, 30 patients and 30 healthy people were selected. The miR-155 and CEA mRNA levels in their peripheral blood were measured and evaluated using real-time polymerase chain reaction (real-time PCR) technique. Findings: Positive miR-155 marker was observed in 21 people from 30 with oral cancer, and 7 of 30 healthy subjects. The CEA mRNA marker was positive in 23 of the 30 patients, and 5 out of 30 healthy subjects. Conclusion: In sum, the outcome of this study can be seen as a screening diagnostic test for early detection of the disease in the early stages. © 2019, Isfahan University of Medical Sciences(IUMS). All rights reserved.
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