Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Micrornas Function in Dental Stem Cells As a Promising Biomarker and Therapeutic Target for Dental Diseases Publisher Pubmed



Nasiri K1 ; Jahri M2 ; Kolahdouz S3 ; Soleimani M4 ; Makiya A5 ; Saini RS6 ; Merza MS7 ; Yasamineh S8 ; Banakar M9, 10 ; Yazdanpanah MH11
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Dentistry, Islamic Azad University, Tehran, Iran
  2. 2. Dental Research Center, School of Dentistry, Shahid Beheshti, Research Institute of Dental Sciences, University of Medical Sciences, Tehran, Iran
  3. 3. Shahid Sadoughi University of Medical Science, Yazd, Iran
  4. 4. Orthodontist, Private Practice, Tehran, Iran
  5. 5. Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Science, Mashhad, Iran
  6. 6. COAMS, King Khalid University, Abha, 62529, Saudi Arabia
  7. 7. Prosthetic Dental Techniques Department, Al-Mustaqbal University College, Babylon, 51001, Iraq
  8. 8. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
  9. 9. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Pediatric Dentistry, Faculty of Dentistry, Shahed University, Tehran, Iran
  11. 11. Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Molecular Diagnosis and Therapy Published:2023


Abstract

Undifferentiated, highly proliferative, clonogenic, and self-renewing dental stem cells have paved the way for novel approaches to mending cleft palates, rebuilding lost jawbone and periodontal tissue, and, most significantly, recreating lost teeth. New treatment techniques may be guided by a better understanding of these cells and their potential in terms of the specificity of the regenerative response. MicroRNAs have been recognized as an essential component in stem cell biology due to their role as epigenetic regulators of the processes that determine stem cell destiny. MicroRNAs have been proven to be crucial in a wide variety of molecular and biological processes, including apoptosis, cell proliferation, migration, and necrocytosis. MicroRNAs have been recognized to control protein translation, messenger RNA stability, and transcription and have been reported to play essential roles in dental stem cell biology, including the differentiation of dental stem cells, the immunological response, apoptosis, and the inflammation of the dental pulp. Because microRNAs increase dental stem cell differentiation, they may be used in regenerative medicine to either preserve the stem cell phenotype or to aid in the development of tooth tissue. The development of novel biomarkers and therapies for dental illnesses relies heavily on progress made in our knowledge of the roles played by microRNAs in regulating dental stem cells. In this article, we discuss how dental stem cells and their associated microRNAs may be used to cure dental illness. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
Related Docs
View other Related Docs
1. The Role of Dental-Derived Stem Cell-Based Therapy and Their Derived Extracellular Vesicles in Post-Covid-19 Syndrome-Induced Tissue Damage, Stem Cell Reviews and Reports (2024)
2. Micrornas-Mediated Regulation of the Differentiation of Dental Pulp-Derived Mesenchymal Stem Cells: A Systematic Review and Bioinformatic Analysis, Stem Cell Research and Therapy (2023)
3. Mesenchymal Stem Cell-Based Scaffolds in Regenerative Medicine of Dental Diseases, Stem Cell Reviews and Reports (2024)
4. 3D Printing in Oral & Maxillofacial Surgery, 3D Printing in Oral & Maxillofacial Surgery (2021)
5. A State-Of-The-Art Review of the Recent Advances in Drug Delivery Systems for Different Therapeutic Agents in Periodontitis, Journal of Drug Targeting (2025)
6. Recent Advances on High-Efficiency of Micrornas in Different Types of Lung Cancer: A Comprehensive Review, Cancer Cell International (2023)
7. Application of Biocompatible Scaffolds in Stem-Cell-Based Dental Tissue Engineering, Advances in Experimental Medicine and Biology (2023)
8. Spotlight on the Impact of Viral Infections on Hematopoietic Stem Cells (Hscs) With a Focus on Covid-19 Effects, Cell Communication and Signaling (2023)
Experts (# of related papers)
View all Related Experts
SeyedMohamad Hosseini Hooshiyar (3)
Dorara Dortaj (2)
Other Related Docs
9. Bone Tissue Engineering Using Human Cells: A Comprehensive Review on Recent Trends, Current Prospects, and Recommendations, Applied Sciences (Switzerland) (2019)
10. The Potential Use of Bacteria and Bacterial Derivatives As Drug Delivery Systems for Viral Infection, Virology Journal (2023)
11. A State-Of-The-Art Review on the Micrornas Roles in Hematopoietic Stem Cell Aging and Longevity, Cell Communication and Signaling (2023)
12. The Salivary Exosomal Microrna As a Potential Biomarker in Patients With Periodontitis and Oral Cancers, Chemical Biology and Drug Design (2023)
13. Therapeutic and Diagnostic Applications of Nanoparticles in the Management of Covid-19: A Comprehensive Overview, Virology Journal (2022)
14. Potential Use of the Cholesterol Transfer Inhibitor U18666a As an Antiviral Drug for Research on Various Viral Infections, Microbial Pathogenesis (2023)
15. Tissue Engineering: Dentin – Pulp Complex Regeneration Approaches (A Review), Tissue and Cell (2017)
16. In Vitro Investigation of Canine Periodontal Ligament-Derived Mesenchymal Stem Cells: A Possibility of Promising Tool for Periodontal Regeneration, Journal of Oral Biology and Craniofacial Research (2023)
17. Photobiomodulation Effects on Periodontal Ligament Stem Cells: A Systematic Review of in Vitro Studies, Current Stem Cell Research and Therapy (2024)
18. Teeth-Derived Stem Cells: A Source for Cell Therapy, Journal of Cellular Physiology (2019)
19. Comparative Biocompatibility and Odonto-/Osteogenesis Effects of Hydraulic Calcium Silicate-Based Cements in Simulated Direct and Indirect Approaches for Regenerative Endodontic Treatments: A Systematic Review, Journal of Functional Biomaterials (2023)
20. The Role of Bismuth Nanoparticles in the Inhibition of Bacterial Infection, World Journal of Microbiology and Biotechnology (2023)
21. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
22. The Potential Use of Bacteria and Their Derivatives As Delivery Systems for Nanoparticles in the Treatment of Cancer, Journal of Drug Targeting (2025)
23. Extracellular Vesicles in Bone and Periodontal Regeneration: Current and Potential Therapeutic Applications, Cell and Bioscience (2021)
24. The Current Applications of Nano and Biomaterials in Drug Delivery of Dental Implant, BMC Oral Health (2024)
25. Transdifferentiation of Periodontal Ligament Stem Cells Into Acinar Cells Using an Indirect Co-Culture System, Cell and Tissue Banking (2023)
26. Unpredictable Outcomes of a Regenerative Endodontic Treatment, Case Reports in Dentistry (2021)
27. Cell Homing Strategy As a Promising Approach to the Vitality of Pulp-Dentin Complexes in Endodontic Therapy: Focus on Potential Biomaterials, Expert Opinion on Biological Therapy (2022)
28. Recent Advances in Nanomaterial-Based Biosensor for Periodontitis Detection, Journal of Biological Engineering (2024)
29. Uses of Pomegranate in Dentistry: A Comprehensive Review of Literature, Malaysian Journal of Medicine and Health Sciences (2024)
30. Exosomes Derived From Mesenchymal Stem Cells: Heralding a New Treatment for Periodontitis?, Tissue and Cell (2023)
31. Recent Advances in Metal Nanoparticles to Treat Periodontitis, Journal of Nanobiotechnology (2023)
32. Effect of Photobiomodulation on Structure and Function of Extracellular Vesicle Secreted From Mesenchymal Stem Cells, Photochemistry and Photobiology (2022)
33. The Role of Non-Coding Rnas in the Diagnosis of Different Stages (Hcc, Chb, Obi) of Hepatitis B Infection, Microbial Pathogenesis (2023)
34. An Overview of the Role of Niemann-Pick C1 (Npc1) in Viral Infections and Inhibition of Viral Infections Through Npc1 Inhibitor, Cell Communication and Signaling (2023)
35. The Potential Use of Mesenchymal Stem Cells-Derived Exosomes As Micrornas Delivery Systems in Different Diseases, Cell Communication and Signaling (2023)
36. Increasing the Sensitivity and Accuracy of Detecting Exosomes As Biomarkers for Cancer Monitoring Using Optical Nanobiosensors, Cancer Cell International (2024)
37. The Current Techniques in Dorsal Augmentation Rhinoplasty: A Comprehensive Review, Maxillofacial Plastic and Reconstructive Surgery (2024)
38. Efficacy of Application of Periodontal Ligament Stem Cells in Bone Regeneration: A Systematic Review of Animal Studies, Dental Hypotheses (2022)
39. A State-Of-The-Art Review of the Recent Advances in Exosome Isolation and Detection Methods in Viral Infection, Virology Journal (2024)
40. Effect of Photobiomodulation Therapy With 660 and 980 Nm Diode Lasers on Differentiation of Periodontal Ligament Mesenchymal Stem Cells, Scientific Reports (2024)
41. Dental Implant Considerations in Patients With Systemic Diseases: An Updated Comprehensive Review, Journal of Oral Rehabilitation (2024)
42. Histopathological Comparison Between Bone Marrow- and Periodontium-Derived Stem Cells for Bone Regeneration in Rabbit Calvaria, International Journal of Organ Transplantation Medicine (2016)
43. Spotlight on Therapeutic Efficiency of Green Synthesis Metals and Their Oxide Nanoparticles in Periodontitis, Journal of Nanobiotechnology (2024)
44. Tissue Engineering Innovations to Enhance Osseointegration in Immediate Dental Implant Loading: A Narrative Review, Cell Biochemistry and Function (2024)
45. The Photobiomodulation Effects of Continuous and Pulsed Blue Diode Laser on Proliferation and Osteogenic Differentiation of Periodontal Ligament Stem Cells, Photochemistry and Photobiology (2025)
46. Advanced Micro-/Nanotechnologies for Exosome Encapsulation and Targeting in Regenerative Medicine, Clinical and Experimental Medicine (2023)