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Kaolin-Loaded Chitosan/Polyvinyl Alcohol Electrospun Scaffold As a Wound Dressing Material: In Vitro and in Vivo Studies Publisher Pubmed



Salehi M1, 2 ; Farzamfar S3 ; Ehterami A4 ; Paknejad Z5, 6 ; Bastami F7, 8 ; Shirian S9, 10 ; Vahedi H11 ; Koehkonan GS12 ; Goodarzi A13
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  2. 2. Tissue Engineering and Stem Cell Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  5. 5. Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Behest University of Medical Sciences, Tehran, Iran
  8. 8. Oral and Maxillofacial Surgery Department, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
  10. 10. Shiraz Molecular Pathology Research Center, Dr. Daneshbod Pathology Lab, Shiraz, Iran
  11. 11. Clinical Research Development Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud, Iran
  12. 12. Department of Medical Nanotechnology, Islamic Azad University Tehran branch, Tehran, Iran
  13. 13. Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

Source: Journal of Wound Care Published:2020


Abstract

Objective: To evaluate the application of a fabricated dressing containing kaolin for skin regeneration in a rat model of excisional wounds. Method: In the present study, kaolin was loaded into electrospun polyvinyl alcohol (PVA)/chitosan polymer blend to develop a composite nanofibrous dressing. To make the yarns, kaolin with weight ratio of 5% was added to PVA/chitosan polymer blend and subsequently formed into nanofibres using the electrospinning method. Scaffolds were evaluated for to their microstructure, mechanical properties, surface wettability, water vapour transmission rate, water-uptake capacity, blood uptake capacity, blood compatibility, microbial penetration test, the number of colonies, and cellular response with the L929 cell line. Rats with full-thickness excisional wounds were treated with kaolin-containing and kaolin-free dressings. Results: The study showed that rats treated with the kaolin-incorporated mats demonstrated a significant closure to nearly 97.62±4.81% after 14 days compared with PVA/chitosan and the sterile gauze, which showed 86.15±8.11% and 78.50±4.22% of wound closure, respectively. The histopathological studies showed that in the PVA/chitosan/kaolin group, dense and regular collagen fibres were formed, while wounds treated with sterile gauze or PVA/chitosan scaffolds had random and loose collagen fibres. Conclusion: Our results show the potential applicability of PVA/chitosan/kaolin scaffolds as a wound care material. Declaration of interest: The authors have no conflicts of interest. © 2018 MA Healthcare ltd
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