Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds

Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds Publisher

Etemadinia A¹ ; Seyfoori A² ; Foroushani AR¹ ; Fard RMN^{1, 3} ; Bakhtiari R¹

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1. Department of Pathobiology, School of Public Health, Tehran University of Medical Science, Tehran, Iran
2. Department of Biomaterials and Tissue Engineering, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran
3. Food Microbiology Research Center, Tehran University of Medical Science, Tehran, Iran

Source: Avicenna Journal of Medical Biotechnology Published:2022

Abstract

Background: Biofilm formation helps Pseudomonas aeruginosa (P. aeruginosa) sur-vive in various environments. Microgels can be effective in treatment of bacterial in-fections. The major aim of this study was to investigate effects of poly-N-isopropyl-acrylamide microgels (PNIPAM) on P. aeruginosa. Methods: Totally, 100 P. aeruginosa strains were isolated from chronic wound infections. Quantitative assessments of biofilm formation and antibiotic susceptibility were carried out. Furthermore, algD, lasR, and PA2714 genes were amplified to investigate gene frequencies and expression rates. Results: Significant decreases were seen in lasR expression in EDTA-treated samples. Significant decreases were observed in expression of algD and lasR treated with xylitol. Decreased expression of PA2714 was seen in samples treated with xylitol with no sig-nificance. Conclusion: The PNIPAM containing xylitol or EDTA could penetrate biofilms of P. aeruginosa and significantly decrease expression of lasR and algD. This can be a novel strategy in the management of chronic wounds. © 2022, Avicenna Journal of Medical Biotechnology. All rights reserved.

Style	Citing Format
MLA	Etemadinia A, et al.. "Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds." Avicenna Journal of Medical Biotechnology, vol. 14, no. 4, 2022, pp. 317-320.
APA	Etemadinia A, Seyfoori A, Foroushani AR, Fard RMN, Bakhtiari R (2022). Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds. Avicenna Journal of Medical Biotechnology, 14(4), 317-320.
Chicago	Etemadinia A, Seyfoori A, Foroushani AR, Fard RMN, Bakhtiari R. "Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds." Avicenna Journal of Medical Biotechnology 14, no. 4 (2022): 317-320.
Harvard	Etemadinia A et al. (2022) 'Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds', Avicenna Journal of Medical Biotechnology, 14(4), pp. 317-320.
Vancouver	Etemadinia A, Seyfoori A, Foroushani AR, Fard RMN, Bakhtiari R. Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds. Avicenna Journal of Medical Biotechnology. 2022;14(4):317-320.
BibTex	@article{ author = {Etemadinia A and Seyfoori A and Foroushani AR and Fard RMN and Bakhtiari R}, title = {Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds}, journal = {Avicenna Journal of Medical Biotechnology}, volume = {14}, number = {4}, pages = {317-320}, year = {2022} }
RIS	TY - JOUR AU - Etemadinia A AU - Seyfoori A AU - Foroushani AR AU - Fard RMN AU - Bakhtiari R TI - Effects of Poly-N-Isopropylacrylamide Microgels Containing Antibiofilm Substances on Pseudomonas Aeruginosa Isolated From Chronic Wounds JO - Avicenna Journal of Medical Biotechnology VL - 14 IS - 4 SP - 317 EP - 320 PY - 2022 ER -

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