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Development and Validation of a Multi-Residue Method for Determination of Antimicrobial Sulfonamides, Macrolides and Quinolones in Iranian Feta Cheese by Spe Clean-Up and Lc-Ms/Ms Publisher



Ghareghani S1 ; Goudarzi S2 ; Amirahmadi M2, 3 ; Kheirandish S1 ; Ghafari H1 ; Daraei B4 ; Ghazikhansari M1
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Food and Drug Reference Control Laboratories, Food and Drug Organisation, MOH & ME, Tehran, Iran
  3. 3. Food and Drug Laboratory Research Centre, Food and Drug Organisation, MOH & ME, Tehran, Iran
  4. 4. Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Science, Tehran, Iran

Source: International Dairy Journal Published:2023


Abstract

A selective and sensitive multi-residue/multi-class ultra-performance liquid chromatography–tandem mass spectrometry method has been validated for simultaneous analysis of 25 antibiotic residues belong to sulfonamides, macrolides, and quinolones groups, as well as griseofulvin and trimethoprim, in Iranian feta cheese samples. Two specific precursor – product ion transitions were acquired per target compound by a positive electrospray ionisation in multiple reaction monitoring mode. Results were obtained as follows: limit of detection (LOD) and limit of quantification (LOQ) were respectively 3.3 ng g−1 and 10 ng g−1 (except for josamycin, LOD: 8.33 and LOQ: 25 ng g−1). Average recovery ranged between 70% and 120% and relative standard deviation of repeatability was lower than 20%. Finally, the method was applied to determination of target analytes in feta cheese samples obtained from the local hypermarkets and traditional dairy product markets in Tehran, Iran. © 2022 Elsevier Ltd
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