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The Effect of Fibronectin on Structural and Biological Properties of Single Walled Carbon Nanotube Publisher



Mottaghitalab F1 ; Farokhi M2 ; Atyabi F3 ; Omidvar R4 ; Shokrgozar MA4 ; Sadeghizadeh M5
Authors
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Authors Affiliations
  1. 1. Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. Pasteur Institute, National cell bank of Iran, Tehran, Iran
  3. 3. Department of Pharmaceutical Nanoechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  5. 5. Department Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Source: Applied Surface Science Published:2015


Abstract

Despite the attractive properties of carbon nanotubes (CNTs). cytoxicity and hydrophobicity are two main considerable features which limit their application in biomedical fields. It was well established that treating CNTs with extracellular matrix components could reduce these unfavourable characteristics. In an attempt to address these issues, fibronectin (FN) with different concentrations was loaded on single walled carbon nanotubes (SWCNTs) substrate. Scanning electron microscope, atomic force microscopy (AFM), contact angles and X-ray photoelectron spectroscopy (XPS) were preformed in order to characterize FN loaded SWCNTs substrates. According to XPS and AFM results. FN could interact with SWCNTs and for this, the hydrophilicity of SWCNTs was improved. Additionally. SWCNT modified with FN showed less cytotoxicity compared with neat SWCNT. Finally. FN was shown to act as an interesting extracellular component for enhancing the biological properties of SWCNT. © 2015 Elsevier B.V. All rights reserved.
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