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Immunomodulatory Effect of N-Acetyl-Seryl-Aspartyl-Proline and Vasoactive Intestinal Peptide on Chronic Obstructive Pulmonary Disease Pathophysiology Publisher Pubmed



Cai J1 ; Chen Q2 ; Mehrabi Nasab E3 ; Athari SS4
Authors
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Authors Affiliations
  1. 1. Department of Emergency, The Second Hospital of Shandong University, Jinan City, China
  2. 2. Department of General Surgery and Critical Care Unit, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Chongming Brangch, Shanghai, China
  3. 3. Department of Cardiology, School of Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran

Source: Fundamental and Clinical Pharmacology Published:2022


Abstract

Chronic obstructive pulmonary disease (COPD) as an inflammatory respiratory system disease is caused by exposure to cigarette smoke and tobacco in long-term. Some anti-inflammatory peptides can control inflammation in COPD. N-acetyl-seryl-aspartyl-proline (Ac-SDKP) and vasoactive intestinal peptide (VIP) as peptide have anti-inflammatory effect, and, in this study, the effect of Ac-SDKP and VIP on COPD inflammation was studied. After producing cigarette smoke-induced COPD mice model, which were treated with VIP and Ac-SDKP, the levels of antioxidant-related factors (malondialdehyde (MDA) and superoxide dismutase (SOD)), fibrotic factors (hydroxyproline (HP) and TGF-β), pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6), and inflammation in histopathological examination were studied. MDA, Remodeling factors, pro-inflammatory cytokines, and inflammation in lung tissue were controlled by VIP and Ac-SDKP treatment. These treatments could enhance SOD. VIP and Ac-SDKP as immuno-regulatory factors had benefit effect in treatment of COPD. The anti-inflammatory, anti-fibrosis, and anti-oxidant properties of VIP and Ac-SDKP may be effective therapy in COPD. © 2022 Societe Francaise de Pharmacologie et de Therapeutique. Published by John Wiley & Sons Ltd.
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