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Bacterial Biofilm in Colorectal Cancer: What Is the Real Mechanism of Action? Publisher Pubmed



Mirzaei R1 ; Mirzaei H2 ; Alikhani MY1 ; Sholeh M3 ; Arabestani MR1 ; Saidijam M4, 5, 6 ; Karampoor S7 ; Ahmadyousefi Y5, 6 ; Moghadam MS8 ; Irajian GR3 ; Hasanvand H9 ; Yousefimashouf R1
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Molecular Medicine and Genetics, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  7. 7. Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Microbiology, School of Health, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Microbial Pathogenesis Published:2020


Abstract

Human colorectal cancer is the third most common cancer around the world. Colorectal cancer has various risk factors, but current works have bolded a significant activity for the microbiota of the human colon in the development of this disease. Bacterial biofilm has been mediated to non-malignant pathologies like inflammatory bowel disease but has not been fully documented in the setting of colorectal cancer. The investigation has currently found that bacterial biofilm is mediated to colon cancer in the human and linked to the location of human cancer, with almost all right-sided adenomas of colon cancers possessing bacterial biofilm, whilst left-sided cancer is rarely biofilm positive. The profound comprehension of the changes in colorectal cancer can provide interesting novel concepts for anticancer treatments. In this review, we will summarize and examine the new knowledge about the links between colorectal cancer and bacterial biofilm. © 2020
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