Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Emerging Role of Microbiota Derived Outer Membrane Vesicles to Preventive, Therapeutic and Diagnostic Proposes Publisher



Jalalifar S1, 6 ; Morovati Khamsi H2 ; Hosseinifard SR3 ; Karampoor S4 ; Bajelan B5 ; Irajian G1, 6 ; Mirzaei R7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Quality Control, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
  3. 3. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Microbial Biotechnology Research Center, University of Medical Sciences, Tehran, Iran
  7. 7. Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

Source: Infectious Agents and Cancer Published:2023


Abstract

The role of gut microbiota and its products in human health and disease is profoundly investigated. The communication between gut microbiota and the host involves a complicated network of signaling pathways via biologically active molecules generated by intestinal microbiota. Some of these molecules could be assembled within nanoparticles known as outer membrane vesicles (OMVs). Recent studies propose that OMVs play a critical role in shaping immune responses, including homeostasis and acute inflammatory responses. Moreover, these OMVs have an immense capacity to be applied in medical research, such as OMV-based vaccines and drug delivery. This review presents a comprehensive overview of emerging knowledge about biogenesis, the role, and application of these bacterial-derived OMVs, including OMV-based vaccines, OMV adjuvants characteristics, OMV vehicles (in conjugated vaccines), cancer immunotherapy, and drug carriers and delivery systems. Moreover, we also highlight the significance of the potential role of these OMVs in diagnosis and therapy. © 2023, The Author(s).
Related Docs
View other Related Docs
1. Commensal and Pathogenic Bacterial-Derived Extracellular Vesicles in Host-Bacterial and Interbacterial Dialogues: Two Sides of the Same Coin, Journal of Immunology Research (2022)
2. Outer Membrane Vesicles in Gram-Negative Bacteria and Its Correlation With Pathogenesis, Frontiers in Immunology (2025)
3. Extracellular Vesicles Derived From Gastrointestinal Microbiota: A New Approach to Clinical Studies, Journal of Mazandaran University of Medical Sciences (2021)
4. Angioregulatory Role of Mirnas and Exosomal Mirnas in Glioblastoma Pathogenesis, Biomedicine and Pharmacotherapy (2022)
5. The Potential Use of Bacteria and Their Derivatives As Delivery Systems for Nanoparticles in the Treatment of Cancer, Journal of Drug Targeting (2025)
6. Extraction and Evaluation of Outer Membrane Vesicles From Two Important Gut Microbiota Members, Bacteroides Fragilis and Bacteroides Thetaiotaomicron, Cell Journal (2020)
7. Dual Role of Microbiota-Derived Short-Chain Fatty Acids on Host and Pathogen, Biomedicine and Pharmacotherapy (2022)
8. Construction and Assessment of the Immunogenicity and Bactericidal Activity of Fusion Protein Porin a From Neisseria Meningitidis Serogroups a and B Admixed With Omv Adjuvant As a Novel Vaccine Candidate, Iranian Journal of Basic Medical Sciences (2020)
Experts (# of related papers)
View all Related Experts
Hamid Reza Mirzaei (4)
Shahram Rabbani (2)
Other Related Docs
9. Mirnas in Outer Membrane Vesicles of Gut Microbiota: Friend or Foe?, Microbial Pathogenesis (2020)
10. Extracellular Vesicles Biogenesis, Isolation, Manipulation and Genetic Engineering for Potential in Vitro and in Vivo Therapeutics: An Overview, Frontiers in Bioengineering and Biotechnology (2022)
11. Bacterial Components As Naturally Inspired Nano-Carriers for Drug/Gene Delivery and Immunization: Set the Bugs to Work?, Biotechnology Advances (2018)
12. The Emerging Role of Exosomal Mirnas As a Diagnostic and Therapeutic Biomarker in Mycobacterium Tuberculosis Infection, Molecular Medicine (2021)
13. The Regulation of Niemann-Pick C1-Like 1 (Npc1l1) Gene Expression in Opposite Direction by Bacteroides Spp. and Related Outer Membrane Vesicles in Caco-2 Cell Line, Journal of Diabetes and Metabolic Disorders (2020)
14. Intestinal Effect of the Probiotic Escherichia Coli Strain Nissle 1917 and Its Omv, Journal of Diabetes and Metabolic Disorders (2020)
15. The Importance of Intracellular Bacterial Biofilm in Infectious Diseases, Microbial Pathogenesis (2020)
16. Minimal Information for Studies of Extracellular Vesicles (Misev2023): From Basic to Advanced Approaches, Journal of Extracellular Vesicles (2024)
17. Exosome Application in Treatment and Diagnosis of B-Cell Disorders: Leukemias, Multiple Sclerosis, and Arthritis Rheumatoid, Cellular and Molecular Biology Letters (2022)
18. The Therapeutic Potential of Exosome Therapy in Sepsis Management: Addressing Complications and Improving Outcomes”, Cell Biochemistry and Biophysics (2025)
19. Microbiota-Derived Extracellular Vesicles As New Systemic Regulators, Frontiers in Microbiology (2017)
20. Extracellular Vesicles in Bone and Periodontal Regeneration: Current and Potential Therapeutic Applications, Cell and Bioscience (2021)
21. Mesenchymal Stem Cells-Derived Exosomes for Wound Regeneration, Advances in Experimental Medicine and Biology (2018)
22. The Effect of Bacteroides Fragilis and Its Postbiotics on the Expression of Genes Involved in the Endocannabinoid System and Intestinal Epithelial Integrity in Caco-2 Cells, Journal of Diabetes and Metabolic Disorders (2023)
23. Role of Microbiota-Derived Short-Chain Fatty Acids in Nervous System Disorders, Biomedicine and Pharmacotherapy (2021)
24. Cell Type-Specific Extracellular Vesicles and Their Impact on Health and Disease, International Journal of Molecular Sciences (2024)
25. The Footprint of Exosomes in the Radiation-Induced Bystander Effects, Bioengineering (2022)
26. Role of Microbiota-Derived Short-Chain Fatty Acids in Cancer Development and Prevention, Biomedicine and Pharmacotherapy (2021)
27. The Emerging Role of Micrornas in the Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2) Infection, International Immunopharmacology (2021)
28. Immunological Evaluation of an Alginate-Based Conjugate As a Vaccine Candidate Against Pseudomonas Aeruginosa, APMIS (2015)
29. Micrornas and Exosomes: Key Players in Hiv Pathogenesis, HIV Medicine (2020)
30. The Biofilm-Associated Bacterial Infections Unrelated to Indwelling Devices, IUBMB Life (2020)
31. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4Th Edition)1, Autophagy (2021)
32. Advances in Management of Spinal Cord Injury Using Stem Cell-Derived Extracellular Vesicles: A Review Study, Basic and Clinical Neuroscience (2023)
33. Recent Progress in Topical and Transdermal Approaches for Melanoma Treatment, Drug Delivery and Translational Research (2025)
34. Effects of Neural Stem Cell-Derived Extracellular Vesicles on Neuronal Protection and Functional Recovery in the Rat Model of Middle Cerebral Artery Occlusion, Cell Biochemistry and Function (2020)
35. Paper-Based Biosensors As Point-Of-Care Diagnostic Devices for the Detection of Cancers: A Review of Innovative Techniques and Clinical Applications, Frontiers in Oncology (2023)
36. Clonal Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve Mouse Model of Weight Drop-Induced Traumatic Brain Injury Through Reducing Cistauosis and Apoptosis, Experimental Neurology (2023)
37. The Safety and Efficacy of Adipose Tissue-Derived Exosomes in Treating Mild to Moderate Plaque Psoriasis: A Clinical Study, Life Sciences (2024)
38. Improvement, Scaling-Up, and Downstream Analysis of Exosome Production, Critical Reviews in Biotechnology (2020)
39. Helicobacter Pylori Release From Yeast As a Vesicle-Encased or Free Bacterium, Helicobacter (2020)
40. Mesenchymal Stem Cell-Derived Exosomes: A New Therapeutic Approach to Osteoarthritis?, Stem Cell Research and Therapy (2019)
41. Overview of Liquid Biopsy, Liquid Biopsy in Urogenital Cancers and its Clinical Utility (2022)
42. Bacterial Biofilm in Colorectal Cancer: What Is the Real Mechanism of Action?, Microbial Pathogenesis (2020)
43. Application of Stem Cell-Derived Exosomes in Anterior Segment Eye Diseases: A Comprehensive Update Review, Ocular Surface (2025)
44. The Pathogenic, Therapeutic and Diagnostic Role of Exosomal Microrna in the Autoimmune Diseases, Journal of Neuroimmunology (2021)
45. Stimulatory Effects of Lactobacillus Casei Derived Extracellular Vesicles on Toll-Like Receptor 9 Gene Expression and Cytokine Profile in Human Intestinal Epithelial Cells, Journal of Diabetes and Metabolic Disorders (2020)
46. Extracellular Vesicles: Essential Agents in Critical Bone Defect Repair and Therapeutic Enhancement, Molecular Biology Reports (2025)
47. Milk-Derived Extracellular Vesicles: Biomedical Applications, Current Challenges, and Future Perspectives, Journal of Agricultural and Food Chemistry (2024)
48. Extracellular Micro/Nanovesicles Rescue Kidney From Ischemia-Reperfusion Injury, Journal of Cellular Physiology (2019)
49. Mesenchymal Stem Cell Exosomes: A Two-Edged Sword in Cancer Therapy, International Journal of Nanomedicine (2019)
50. Fusobacterium Nucleatum and Colorectal Cancer: A Mechanistic Overview, Journal of Cellular Physiology (2019)