Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Long-Term Graft Survival in a Kidney Transplant Recipient With Glioblastoma: Case Report Publisher



Rahbar M1 ; Latifi M2 ; Pourhosein E3 ; Mahmoudi E4 ; Seyhoun I5 ; Dehghani S3, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Associate professor of nephrology, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Medical ethics and law research center, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran
  3. 3. Organ Procurement Unit, Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Sina Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  5. 5. Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  6. 6. Iranian Tissue Bank & Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Source: Transplantation Reports Published:2024


Abstract

Long-term immunosuppression after transplantation can increase the risk of cancer development in recipient patients. This case report describes the treatment approach for glioblastoma in a kidney transplant recipient after transplantation. The patient, a 61-year-old woman, received a living donor kidney transplant 24 years ago due to congenital nephrotic syndrome. The patient was on various immunosuppressive medications, including cyclosporine, prednisolone, and mycophenolate mofetil. After 16 years of follow-up, the patient presented with symptoms of brain tumor, leading to further tests. Subsequent examination revealed the presence of a tumor that had spread to frontal region within the brain. A surgical procedure was subsequently conducted to extract the tumor cells and alleviate the resulting pressure within the brain. Based on pathology results, it was determined that the patient had glioblastoma. Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) promoter was detected, indicating the potential response to chemotherapy. Chemotherapy was initiated, along with radiation therapy. After the diagnosis and surgery, the patient's medications for the kidney transplant were modified. Rapamycin replaced the previous medications, and the dose of mycophenolate mofetil and prednisolone was decreased. After 7 years, the patient's kidney is functioning well, with a creatinine level of 1.5, and brain imaging showed no abnormalities. After kidney transplantation, there is an increased risk of various cancers. Overall, this case report demonstrates a successful treatment approach for glioblastoma after kidney transplantation, emphasizing the need for close monitoring and individualized management in transplant recipients at risk for cancer development. Considering the current stability of the patient's condition after a change in medication regimen, patients who have been using the drug Cyclosporine for a long time should be included in future evaluations due to its carcinogenic properties. © 2024
Related Docs
1. Choriocarcinoma Transmitted With the Transplant: Case Study, SAGE Open Medical Case Reports (2022)
Experts (# of related papers)
View all Related Experts
Mohsen Taheri Mahmoodi (1)
Hosein Diyalameh (1)