Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial

Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial Publisher Pubmed

Shafizadeh M^{1, 4} ; Farzaneh F¹ ; Kankam SB^{1, 4} ; Jangholi E^{1, 2} ; Shafizadeh Y³ ; Khoshnevisan A^{1, 4}

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1. Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
2. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Internal Medicine, Broward Health Medical Center, Fort Lauderdale, FL, United States
4. International Neurosurgery Group, Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: World Neurosurgery Published:2023

Abstract

Background: Glioblastoma is associated with low median survival time irrespective of maximal treatment. Previous in vitro studies have revealed tumor inhibitory effect of cyclosporine A. However, whether the addition of cyclosporine could improve survival among patients with glioblastoma is unknown. This study aimed to determine the impact of postoperation treatment with cyclosporine on the survival and performance status. Methods: In this randomized, triple-blinded, placebo-controlled trial, 118 patients with glioblastoma who underwent surgery were treated with standard chemoradiotherapy regimen. Patients were randomized to receive intravenous cyclosporine for 3 days postoperatively or placebo during the same period. The primary endpoint was the short-term effect of intravenous cyclosporine on survival and Karnofsky performance scores. Secondary endpoints were chemoradiotherapy toxicity and neuroimaging features. Results: The overall survival (OS) in the cyclosporine (17.03 ± 5.8, 95% confidence interval: 11–17.37 months) group was statistically lower than in the placebo (30.53 ± 4.9, 95% confidence interval: 8–32.3 months) groups (P = 0.049). However, compared to the placebo group, a statistically higher percentage of patients in the cyclosporine group were alive at 12 months follow-up. Also, progression-free survival in the cyclosporine group was significantly prolonged than in the placebo group (6.3 ± 4.07 months vs. 3.4 ± 2.98 months, P < 0.001). In the multivariate analysis, age <50 years (P = 0.022) and gross total resection (P = 0.03) were significantly associated with OS. Conclusions: Our study results demonstrated that administering postoperative cyclosporine does not improve OS and functional performance status. Notably, the survival rate was significantly dependent on the patient age and the extent of glioblastoma resection. © 2023

Style	Citing Format
MLA	Shafizadeh M, et al.. "Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial." World Neurosurgery, vol. 176, no. , 2023, pp. e548-e556.
APA	Shafizadeh M, Farzaneh F, Kankam SB, Jangholi E, Shafizadeh Y, Khoshnevisan A (2023). Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial. World Neurosurgery, 176(), e548-e556.
Chicago	Shafizadeh M, Farzaneh F, Kankam SB, Jangholi E, Shafizadeh Y, Khoshnevisan A. "Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial." World Neurosurgery 176, no. (2023): e548-e556.
Harvard	Shafizadeh M et al. (2023) 'Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial', World Neurosurgery, 176(), pp. e548-e556.
Vancouver	Shafizadeh M, Farzaneh F, Kankam SB, Jangholi E, Shafizadeh Y, Khoshnevisan A. Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial. World Neurosurgery. 2023;176():e548-e556.
BibTex	@article{ author = {Shafizadeh M and Farzaneh F and Kankam SB and Jangholi E and Shafizadeh Y and Khoshnevisan A}, title = {Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial}, journal = {World Neurosurgery}, volume = {176}, number = {}, pages = {e548-e556}, year = {2023} }
RIS	TY - JOUR AU - Shafizadeh M AU - Farzaneh F AU - Kankam SB AU - Jangholi E AU - Shafizadeh Y AU - Khoshnevisan A TI - Effects of Postoperative Intravenous Cyclosporine Treatment on the Survival and Functional Performance Status of Patients With Glioblastoma: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial JO - World Neurosurgery VL - 176 IS - SP - e548 EP - e556 PY - 2023 ER -

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