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Breakthrough Sars-Cov-2 Infections After Vaccination: A Critical Review Publisher Pubmed



Mohseni Afshar Z1 ; Barary M2, 3 ; Hosseinzadeh R4 ; Alijanpour A5 ; Hosseinzadeh D6 ; Ebrahimpour S7 ; Nazary K4 ; Sio TT8 ; Sullman MJM9, 10 ; Carsonchahhoud K11 ; Babazadeh A7
Authors
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Authors Affiliations
  1. 1. Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Student Research Committee, Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Student Research Committee, Babol University of Medical Sciences, Babol, Iran
  5. 5. Faculty of Medicine, Semmelweis University, Budapest, Hungary
  6. 6. O. O. Bogomolets National Medical University, Kyiv, Ukraine
  7. 7. Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  8. 8. Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, United States
  9. 9. Department of Social Sciences, University of Nicosia, Nicosia, Cyprus
  10. 10. Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus
  11. 11. Australian Centre for Precision Health, University of South Australia, Adelaide, Australia

Source: Human Vaccines and Immunotherapeutics Published:2022


Abstract

At the beginning of the current pandemic, it was believed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection would induce lifelong immunity and that reinfections would be unlikely. However, after several cases of reinfection were documented in previously infected patients, this was understood to be a false assumption, and this waning humoral immunity has raised significant concerns. Accordingly, long-term and durable vaccine-induced antibody protection against infection have also become a challenge, as several breakthroughs of COVID-19 infection have been identified in individuals who were fully vaccinated. This review discusses the current evidence on breakthrough COVID-19 infections occurring after vaccination. © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
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