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An Overview on the Treatments and Prevention Against Covid-19 Publisher Pubmed



Panahi Y1 ; Gorabi AM2 ; Talaei S3 ; Beiraghdar F4 ; Akbarzadeh A5 ; Tarhriz V6 ; Mellatyar H1
Authors
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Authors Affiliations
  1. 1. Pharmacotherapy Department, Faculty of Pharmacy, Bagyattallah University of Medical Sciences, Tehran, Iran
  2. 2. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Basic Sciences, Maragheh University of Medical Sciences, Maragheh, Iran
  4. 4. Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Virology Journal Published:2023


Abstract

Background: The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to plague the world. While COVID-19 is asymptomatic in most individuals, it can cause symptoms like pneumonia, ARDS (acute respiratory distress syndrome), and death in others. Although humans are currently being vaccinated with several COVID-19 candidate vaccines in many countries, however, the world still is relying on hygiene measures, social distancing, and approved drugs. Result: There are many potential therapeutic agents to pharmacologically fight COVID-19: antiviral molecules, recombinant soluble angiotensin-converting enzyme 2 (ACE2), monoclonal antibodies, vaccines, corticosteroids, interferon therapies, and herbal agents. By an understanding of the SARS-CoV-2 structure and its infection mechanisms, several vaccine candidates are under development and some are currently in various phases of clinical trials. Conclusion: This review describes potential therapeutic agents, including antiviral agents, biologic agents, anti-inflammatory agents, and herbal agents in the treatment of COVID-19 patients. In addition to reviewing the vaccine candidates that entered phases 4, 3, and 2/3 clinical trials, this review also discusses the various platforms that are used to develop the vaccine COVID-19. © 2023, The Author(s).
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