N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway

N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway Publisher

Aliabadi A^{1, 2} ; Afnanzade NS^{2, 3} ; Hosseinzadeh L^{1, 4} ; Mohammadifarani A^{1, 4} ; Shafiee MH^{2, 3} ; Nazari H^{3, 4} ; Ahmadi F^{1, 4} ; Foroumadi A⁵

Show Affiliations

1. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14174, Iran

Source: Pharmaceutical Chemistry Journal Published:2019

Abstract

New 1,3,4-thiadiazole-based compounds were designed, synthesized, and their anticancer effects were assessed by MTT assay against PC3 (prostate cancer), HT-29 (colon cancer), and SKNMC (neuroblastoma) cell lines. The results were compared to that of doxorubicin. According to MTT assay, some of the synthesized compounds exhibit higher cytotoxic activity (IC 50 , μM range) than doxorubicin against PC3 and SKNMC cells but not HT29 cells. According to the analysis of structure – activity relationship, compounds with methoxy group as an electron donating moiety rendered higher activity than nitro group as an electron withdrawing group. Compound 4d with ortho position of methoxy moiety activated caspases 3 and 9 in both PC3 and HT-29 cell lines. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.

Style	Citing Format
MLA	Aliabadi A, et al.. "N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway." Pharmaceutical Chemistry Journal, vol. 53, no. 6, 2019, pp. 521-526.
APA	Aliabadi A, Afnanzade NS, Hosseinzadeh L, Mohammadifarani A, Shafiee MH, Nazari H, Ahmadi F, Foroumadi A (2019). N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway. Pharmaceutical Chemistry Journal, 53(6), 521-526.
Chicago	Aliabadi A, Afnanzade NS, Hosseinzadeh L, Mohammadifarani A, Shafiee MH, Nazari H, Ahmadi F, Foroumadi A. "N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway." Pharmaceutical Chemistry Journal 53, no. 6 (2019): 521-526.
Harvard	Aliabadi A et al. (2019) 'N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway', Pharmaceutical Chemistry Journal, 53(6), pp. 521-526.
Vancouver	Aliabadi A, Afnanzade NS, Hosseinzadeh L, Mohammadifarani A, Shafiee MH, Nazari H, et al.. N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway. Pharmaceutical Chemistry Journal. 2019;53(6):521-526.
BibTex	@article{ author = {Aliabadi A and Afnanzade NS and Hosseinzadeh L and Mohammadifarani A and Shafiee MH and Nazari H and Ahmadi F and Foroumadi A}, title = {N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway}, journal = {Pharmaceutical Chemistry Journal}, volume = {53}, number = {6}, pages = {521-526}, year = {2019} }
RIS	TY - JOUR AU - Aliabadi A AU - Afnanzade NS AU - Hosseinzadeh L AU - Mohammadifarani A AU - Shafiee MH AU - Nazari H AU - Ahmadi F AU - Foroumadi A TI - N-(5-(Trifluoromethyl)-1,3,4-Thiadiazol-2-Yl)Benzamide and Benzothioamide Derivatives Induce Apoptosis Via Caspase-Dependent Pathway JO - Pharmaceutical Chemistry Journal VL - 53 IS - 6 SP - 521 EP - 526 PY - 2019 ER -

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