Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones

Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones Publisher

Bahadorikhalili S¹ ; Mahdavi M² ; Mamani L³ ; Shafiee A⁴ ; Mahdavi H¹ ; Akbarzadeh T⁴

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, P. O. Box: 14155-6455, Tehran, Iran
2. Endocrinology Metabolism Research Center, Endocrinology Metabolism Clinical Sciences Institute, Tehran University of Medical Science, Tehran, Iran
3. Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: New Journal of Chemistry Published:2018

Abstract

In this paper, a novel methodology is introduced for the synthesis of novel 5-methyl-8H-isoquinolino[1,2-b]quinazolin-8-one derivatives based on an efficient immobilized palladium catalyzed intramolecular carbon-carbon bond formation. The novel catalyst is fabricated by immobilization of Pd on phosphinite polyethyleneimine functionalized Fe3O4@SiO2 core-shell nanoparticles (denoted as Pd@OPPh2-PEI-mSiO2 NPs). In this catalyst, PEI moieties act as both a water dispersant and base in the reaction. In the key step, 3-allyl-2-(2-bromophenyl)-2,3-dihydroquinazolin-4(1H)-ones (3a-i) were synthesized via a cyclization reaction between N-allyl-2-aminobenzamides and 2-bromobenzaldehyde. The latter obtained materials then underwent an intramolecular carbon-carbon bond formation in the presence of the Pd@Ph2PO-PEI-mSiO2 catalyst to give 5-methyl-13,13a-dihydro-8H-isoquinolino[1,2-b]quinazolin-8-ones (4a-i). © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Style	Citing Format
MLA	Bahadorikhalili S, et al.. "Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones." New Journal of Chemistry, vol. 42, no. 7, 2018, pp. 5499-5507.
APA	Bahadorikhalili S, Mahdavi M, Mamani L, Shafiee A, Mahdavi H, Akbarzadeh T (2018). Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones. New Journal of Chemistry, 42(7), 5499-5507.
Chicago	Bahadorikhalili S, Mahdavi M, Mamani L, Shafiee A, Mahdavi H, Akbarzadeh T. "Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones." New Journal of Chemistry 42, no. 7 (2018): 5499-5507.
Harvard	Bahadorikhalili S et al. (2018) 'Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones', New Journal of Chemistry, 42(7), pp. 5499-5507.
Vancouver	Bahadorikhalili S, Mahdavi M, Mamani L, Shafiee A, Mahdavi H, Akbarzadeh T. Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones. New Journal of Chemistry. 2018;42(7):5499-5507.
BibTex	@article{ author = {Bahadorikhalili S and Mahdavi M and Mamani L and Shafiee A and Mahdavi H and Akbarzadeh T}, title = {Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones}, journal = {New Journal of Chemistry}, volume = {42}, number = {7}, pages = {5499-5507}, year = {2018} }
RIS	TY - JOUR AU - Bahadorikhalili S AU - Mahdavi M AU - Mamani L AU - Shafiee A AU - Mahdavi H AU - Akbarzadeh T TI - Palladium Functionalized Phosphinite Polyethyleneimine Grafted Magnetic Silica Nanoparticles As an Efficient Catalyst for the Synthesis of Isoquinolino[1,2-: B] Quinazolin-8-Ones JO - New Journal of Chemistry VL - 42 IS - 7 SP - 5499 EP - 5507 PY - 2018 ER -

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