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Distribution of High-Level Mupirocin Resistance Among Clinical Mrsa Publisher Pubmed



Mahmoodzadeh Hosseini H1 ; Kiyani N2 ; Amin M3 ; Hedayati Ch M4 ; Imani Fooladi AA1
Authors
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Authors Affiliations
  1. 1. Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Biotechnology, Branch Tehran-Shargh, Payame Noor University, Tehran, Iran
  3. 3. Faculty of Pharmacy, Department of Drug and Food Control, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, Parasitology, and Immunology, Guilan University of Medical Sciences, Rasht, Iran

Source: Journal of Chemotherapy Published:2017


Abstract

Mupirocin is a topical antibiotic for methicillin-resistant Staphylococcus aureus (MRSA) decolonization in hospital settings and nursing homes and is used as a highly effective antibiotic against MRSA. In this study, we aimed to evaluate the frequency of high-level mupirocin-resistant (HLMR) strains among the MRSA subtypes. A total of 188 clinical MRSA isolates were collected from 2011 to 2014, and their susceptibility to antimicrobial agents and vancomycin resistance was evaluated using disc diffusion method and micro-dilution method, respectively. Furthermore, the presence of mecA, SSCmec, mupA and mupB was assessed by PCR. All isolates were multi-drug resistant (MDR) but 2 strains (1.06%) were resistant to mupirocin. Minimum inhibitory concentration (MIC) of vancomycin for 8 strains (4.7%) was higher than 2 μg/ml. Of 188 isolates, 188 (100%), 64 (34.04%), 8 (4.3%), 150 (79.8%), 26 (13.8%), 2 (1.06) and 2 (1.06%) isolates possessed mecA, SCCmec types I, II, III, IV, mupA and mupB genes, respectively. Our data showed that despite infection control policy enforced by health care committee, the rate of mupirocin resistance among MRSA strains is continuously rising. © 2016 Edizioni Scientifiche per l'Informazione su Farmaci e Terapia (Italian Society of Chemotherapy).
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