Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Flaxseed Supplementation in Metabolic Syndrome Management: A Pilot Randomized, Open-Labeled, Controlled Study Publisher Pubmed



Yari Z1 ; Rahimlou M2 ; Poustchi H3 ; Hekmatdoost A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Nutrition, School of Nutrition & Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Liver & Hepatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Phytotherapy Research Published:2016


Abstract

The aim of this study was to evaluate the efficacy of flaxseed supplementation plus lifestyle modification in comparison with lifestyle modification alone in the management of metabolic syndrome (MetS). A randomized controlled clinical trial was conducted on 44 patients with MetS. Participants were assigned to receive either the lifestyle advice and 30-g brown milled flaxseed daily or only the lifestyle advice as the control group. The percentage of individuals with MetS decreased from baseline by 50% and 82% in the control and intervention group, respectively. The reversion rate of central obesity was higher in the flaxseed group (36%) than control group (13%). Moreover, greater reduction in insulin resistance was observed in flaxseed group in comparison with control group (p < 0.001). Body weight, waist circumference, and body mass index decreased significantly in both groups with a significantly greater reduction in flaxseed group in comparison with controls (p < 0.05). There were no significant changes in blood pressure in any groups. Our results indicate that co-administration of flaxseed with lifestyle modification is more effective than lifestyle modification alone in management of MetS; whether these effects will be sustained with longer treatment durations remains to be determined. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.
Related Docs
View other Related Docs
1. Flaxseed Supplementation in Non-Alcoholic Fatty Liver Disease: A Pilot Randomized, Open Labeled, Controlled Study, International Journal of Food Sciences and Nutrition (2016)
2. Application of Flaxseed As an Effective Approach for Improving Lipid Profile Parameters: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials, PharmaNutrition (2024)
3. Flaxseed Supplementation Improves Anthropometric Measurements, Metabolic, and Inflammatory Biomarkers in Overweight and Obese Adults, International Journal for Vitamin and Nutrition Research (2022)
4. Effect of Flaxseed Supplementation on Lipid Profile: An Updated Systematic Review and Dose-Response Meta-Analysis of Sixty-Two Randomized Controlled Trials, Pharmacological Research (2020)
5. Assessment of Lean Patients With Non-Alcoholic Fatty Liver Disease in a Middle Income Country; Prevalence and Its Association With Metabolic Disorders: A Cross-Sectional Study, Archives of Iranian Medicine (2017)
6. Interaction Between a Variant of Chromosome 9P21.3 Locus and Diet Antioxidant Capacity on Metabolic Syndrome in Tehrani Adults, Diabetology and Metabolic Syndrome (2018)
7. Does Metabolic Syndrome Increase the Risk of Fracture? a Systematic Review and Meta-Analysis, Archives of Osteoporosis (2022)
8. Exploring Metabolically Healthy Obesity: Prevalence, Characteristics, and Cardiovascular Risk in the Iranian Population Based on the Steps 2021, Journal of Diabetes and Metabolic Disorders (2023)
Experts (# of related papers)
View all Related Experts
Hossein Poustchi (10)
Khadijeh Mirzaei (8)
Other Related Docs
9. Examination of the Relationship Between Metabolic Syndrome and Obstructive Sleep Apnea in Iranian Patients With Type 2 Diabetes: A Case–Control Study, Diabetes# Metabolic Syndrome and Obesity (2020)
10. The Effect of Smoking on Latent Hazard Classes of Metabolic Syndrome Using Latent Class Causal Analysis Method in the Iranian Population, BMC Public Health (2023)
11. Effect of Flaxseed Supplementation on Markers of Inflammation and Endothelial Function: A Systematic Review and Meta-Analysis, Cytokine (2020)
12. Longitudinal Association Between Body Mass Index and Physical Activity Among Adolescents With Different Parental Risk: A Parallel Latent Growth Curve Modeling Approach, International Journal of Behavioral Nutrition and Physical Activity (2020)
13. Vitamin D Deficiency Is Associated With Insulin Resistance in Nondiabetics and Reduced Insulin Production in Type 2 Diabetics, Hormone and Metabolic Research (2015)
14. Relationships Between the Intake of Milk Fat Percentage and Cardio-Metabolic Indices in Adult Men: Results From a Cross-Sectional Study, Iranian Journal of Nutrition Sciences and Food Technology (2024)
15. Maternal Characteristics and Incidence of Overweight/Obesity in Children: A 13-Year Follow-Up Study in an Eastern Mediterranean Population, Maternal and Child Health Journal (2017)
16. The Interaction Between Cry1 Polymorphism and Alternative Healthy Eating Index (Ahei) on Cardiovascular Risk Factors in Overweight Women and Women With Obesity: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
17. Association of Nightly Fasting Duration, Meal Timing and Frequency With the Metabolic Syndrome Among Iranian Adults, British Journal of Nutrition (2023)
18. Effect of the Herbal Medicines in Obesity and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials, Phytotherapy Research (2020)
19. Sodium Status and the Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies, Critical Reviews in Food Science and Nutrition (2019)
20. The Risk of Metabolic Syndrome in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis, Clinical Endocrinology (2018)
21. A Nationwide Study of Metabolic Syndrome Prevalence in Iran; a Comparative Analysis of Six Definitions, PLoS ONE (2021)
22. Early Postpartum Glucose Intolerance, Metabolic Syndrome and Gestational Diabetes Mellitus Determinants After Assisted Conception: A Prospective Cohort Study, International Journal of Fertility and Sterility (2022)
23. Distribution of Body Mass Index in Children With Different Parental Risk: Findings of a Family-Based Cohort Study in a West-Asian Population, Scientific Reports (2019)
24. The Effects of Smoking on Metabolic Syndrome and Its Components Using Causal Methods in the Iranian Population, International Journal of Preventive Medicine (2021)
25. The Effect of Flaxseed Oil Supplementation on Body Composition and Inflammation Indices in Overweight Adults With Pre-Diabetes, Nutrition and Metabolic Insights (2022)
26. Vitamin D3 Supplementation Improves Serum Sfrp5 and Wnt5a Levels in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial, International Journal for Vitamin and Nutrition Research (2018)
27. The Effect of a Cognitive Behavioral Program Based on an Interactive Application on Serum Glucose Levels and Hba1c of Family Members of Patients With Type 2 Diabetes: A Study Protocol for a Randomized Clinical Trial, Journal of Diabetes and Metabolic Disorders (2023)
28. The Possible Mediatory Role of Inflammatory Markers on the Association of Dietary Insulin Index and Insulin Load With Metabolic Syndrome in Women With Overweight and Obesity: A Cross-Sectional Study, International Journal of Clinical Practice (2023)
29. The Pattern of Medication Use, and Determinants of the Prevalence of Polypharmacy Among Patients With a Recent History of Depressive Disorder: Results From the Pars Cohort Study, BMC Psychology (2022)
30. Sumac Fruit Supplementation Improve Glycemic Parameters in Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis, Phytomedicine (2021)
31. Effect of Caring Intervention on Preeclampsia in Pregnant Women With Metabolic Syndrome: A Randomized Controlled Trial, Journal of Nursing and Midwifery Sciences (2022)
32. Predicting Metabolic Syndrome by Visceral Adiposity Index, Body Roundness Index and a Body Shape Index in Adults: A Cross-Sectional Study From the Iranian Rancd Cohort Data, Diabetes# Metabolic Syndrome and Obesity (2020)
33. Sex-Specific Incidence Rates and Risk Factors for Hypertension During 13 Years of Follow-Up: The Tehran Lipid and Glucose Study, Global Heart (2020)
34. Optimal Cut-Points of Different Anthropometric Indices and Their Joint Effect in Prediction of Type 2 Diabetes: Results of a Cohort Study, BMC Public Health (2018)
35. Prevalence of Vitamin D Deficiency and Its Association With Metabolic Syndrome Among the Elderly Population of Birjand, Iran, Journal of Diabetes and Metabolic Disorders (2022)
36. The Effect of Hesperidin Supplementation on Metabolic Profiles in Patients With Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, European Journal of Nutrition (2020)
37. The Association of Dietary Energy Density and the Risk of Obesity, Type 2 Diabetes and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Observational Studies, International Journal of Clinical Practice (2021)
38. The Effects of Cpap Therapy on Metabolic Profile and Subjective Sleep Parameters in Patients With Osa: A Prospective Trial Study, Sleep Science (2022)
39. International Waist Circumference Percentile Cutoffs for Central Obesity in Children and Adolescents Aged 6 to 18 Years, Journal of Clinical Endocrinology and Metabolism (2020)
40. Association of Dietary and Lifestyle Inflammation Score With Metabolic Syndrome in a Sample of Iranian Adults, Frontiers in Nutrition (2021)
41. Effects of a Healthy Lifestyle Education on the Incidence of Metabolic Syndrome in Children During a 13-Year Follow-Up, International Journal of Behavioral Medicine (2018)
42. Variations in Serum Free Thyroxine Concentration Within the Reference Range Predicts the Incidence of Metabolic Syndrome in Non-Obese Adults: A Cohort Study, Thyroid (2017)
43. Habitual- and Meal-Specific Carbohydrate Quality Index and Their Relation to Metabolic Syndrome in a Sample of Iranian Adults, Frontiers in Nutrition (2022)
44. Non-High-Density Lipoprotein Fractions Are Strongly Associated With the Presence of Metabolic Syndrome Independent of Obesity and Diabetes: A Population-Based Study Among Iranian Adults, Journal of Diabetes and Metabolic Disorders (2017)
45. Association of the Elderly Dietary Index With Cardiovascular Disease Risk Factors in Elderly Men: A Cross-Sectional Study, Nutrition and Dietetics (2019)
46. Prevalence of Metabolic Syndrome and Its Components in the Iranian Adult Population: A Systematic Review and Meta-Analysis, Iranian Red Crescent Medical Journal (2015)
47. The Six Obesity Indices, Which One Is More Compatible With Metabolic Syndrome? a Population Based Study, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
48. The Prevalence of Metabolic Syndrome and Different Obesity Phenotype in Iranian Male Military Personnel, American Journal of Men's Health (2017)
49. The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients With Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Hormone and Metabolic Research (2017)
50. The Accuracy of Triglyceride-Glucose (Tyg) Index for the Screening of Metabolic Syndrome in Adults: A Systematic Review and Meta-Analysis, Nutrition# Metabolism and Cardiovascular Diseases (2022)