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Investigation of Antitumor Effects of Lactobacillus Crispatus in Experimental Model of Breast Cancer in Balb/C Mice Publisher Pubmed



Motevaseli E1, 2 ; Khorramizadeh MR3, 4 ; Hadjati J5 ; Bonab SF5 ; Eslami S6 ; Ghafourifard S7
Authors
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Authors Affiliations
  1. 1. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Biosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
  7. 7. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Immunotherapy Published:2018


Abstract

Aim: To evaluate the effect of intraperitoneal injections of heat-killed Lactobacillus crispatus on breast tumor size and overall survival of Balb/c mouse received 4T1 mammary carcinoma. Materials and methods: Different doses of L. crispatus have been injected intraperitoneally in BALB/c mice. Results: Tumor size was decreased in the experiment group treated with 1 × 108 bacteria/200 μl. Treatment with 1 × 108 bacteria/200 μl resulted in survival improvement. The myeloid-derived suppressor cells and reactive oxygen species production have been increased in all groups. Cox2 expression decreased in tumor tissues of the mice treated with 108 bacteria/200 μl. The expressions of Arginase and iNos increased in the spleen and tumor tissues of those treated with 5 × 108 bacteria/200 μl. Conclusion: We have shown the protective effect of L. crispatus on survival of tumor-bearing mice. © 2018 2017 Future Medicine Ltd.
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